吴月,徐艳,黄鑫,王大可,黄晨韵,梁素改.精神分裂症患者外周色氨酸-犬尿氨酸代谢通路中代谢物水平与临床症状的关系[J].四川精神卫生杂志,2024,37(1):6-10.Wu Yue,Xu Yan,Huang Xin,Wang Dake,Huang Chenyun,Liang Sugai,Relationship between metabolites of peripheral tryptophan-kynurenine metabolic pathway and clinical symptoms in patients with schizophrenia[J].SICHUAN MENTAL HEALTH,2024,37(1):6-10

Relationship between metabolites of peripheral tryptophan-kynurenine metabolic pathway and clinical symptoms in patients with schizophrenia

DOI：10.11886/scjsws20231101001

English keywords:Schizophrenia Serum Urine Tryptophan Kynurenine Metabolites Clinical symptoms

Fund projects:浙江省医药卫生科技计划项目（项目名称：尿液犬尿氨酸代谢物对首发精神分裂症早期诊断应用探索研究，项目编号：2022KY990）

Author Name	Affiliation	Postcode
Wu Yue	Affiliated Mental Health Center， Zhejiang University School of Medicine， Hangzhou Seventh People's Hospital， Hangzhou 310013， China	310013
Xu Yan	Affiliated Mental Health Center， Zhejiang University School of Medicine， Hangzhou Seventh People's Hospital， Hangzhou 310013， China	310013
Huang Xin	Affiliated Mental Health Center， Zhejiang University School of Medicine， Hangzhou Seventh People's Hospital， Hangzhou 310013， China	310013
Wang Dake	Affiliated Mental Health Center， Zhejiang University School of Medicine， Hangzhou Seventh People's Hospital， Hangzhou 310013， China	310013
Huang Chenyun	Affiliated Mental Health Center， Zhejiang University School of Medicine， Hangzhou Seventh People's Hospital， Hangzhou 310013， China	310013
Liang Sugai	Affiliated Mental Health Center， Zhejiang University School of Medicine， Hangzhou Seventh People's Hospital， Hangzhou 310013， China	310013

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Background Schizophrenia is a common severe mental disorder with complex pathogenesis. There are few studies on the correlation between kynurenine metabolites in peripheral serum and urine in schizophrenia.Objective To investigate the concentration of tryptophan-kynurenine metabolites and interleukin-6 （IL-6） in serum and urine in patients with schizophrenia， and their correlation with clinical symptoms， so as to explore potential biological characteristics related to schizophrenia.Methods A total of 38 patients with schizophrenia who met the criteria of the Diagnostic and Statistical Manual of Mental Disorders， fifth edition （DSM-5）， and were hospitalized or attended outpatient clinic at Hangzhou Seventh People's Hospital from December 2021 to December 2022 were included in the study. Additionally， 26 healthy individuals were concurrently recruited from the community of Hangzhou to serve as a control group. All participants were requested to complete the Positive and Negative Symptom Scale （PANSS）. The levels of tryptophan （TRP）， kynurenine （KYN）， kynurenic acid （KYNA）， quinolinic acid （QUIN）， picolinic acid （PIC）， xanthurenate and 5-hydroxytryptamine （5-HT） in both serum and urine were measured using ultra-high-performance liquid chromatography-triple quadrupole linear ion trap mass spectrometry. Serum and urine IL-6 were measured using enzyme-linked immunosorbent assay. Pearson correlation analysis was conducted to examine the correlation between serum and urinary KYN metabolites， as well as the correlation between metabolite levels and clinical symptoms in the patient group.Results Patients with schizophrenia had significantly higher level of IL-6 in serum （U=798.500， P<0.01） and lower level of PIC in urine （U=253.000， P=0.013） compared with the control group. Additionally， level of serum KYN was positively correlated with QUIN/KYNA ratio and QUIN/PIC ratio （r=0.562， 0.438， P<0.05） in patients with schizophrenia. 5-HT/KYN ratio in serum was positively correlated with PANSS total score and negative symptom subscale score （r=0.458， 0.455， P<0.01） in patients with schizophrenia.Conclusion Serum TRP-KYN pathway metabolite levels in patients with schizophrenia were associated with neurotoxic metabolite ratios in urine and the severity of negative symptoms. ［Funded by Zhejiang Medical and Health Science and Technology Program Exploratory （number， 2022KY990）］

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