| 肖林,张小梅,吴凯,王陆.高压氧治疗抑郁症的效果及机制研究进展[J].四川精神卫生杂志,2024,37(1):91-96.Xiao Lin,Zhang Xiaomei,Wu Kai,Wang Lu,Research progress in the effectiveness and mechanism of hyperbaric oxygen therapy for depression[J].SICHUAN MENTAL HEALTH,2024,37(1):91-96 |
| 高压氧治疗抑郁症的效果及机制研究进展 |
| Research progress in the effectiveness and mechanism of hyperbaric oxygen therapy for depression |
| 投稿时间：2023-02-08 |
| DOI：10.11886/scjsws20230208003 |
| 中文关键词: 高压氧 抑郁症 神经炎症 突触可塑性 |
| 英文关键词:Hyperbaric oxygen Depression Neuroinflammation Synaptic plasticity |
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| 中文摘要: |
| 目前，高压氧疗法因副作用少且操作方便的特点，可作为治疗抑郁症的潜在方法。本文通过综述高压氧治疗抑郁症的临床应用现状和作用机制，以期为抑郁症治疗新策略的制定提供参考。高压氧疗法现已被作为抑郁症患者的有效疗法，可通过调节下丘脑-垂体-肾上腺轴、抑制神经炎症以及增强突触可塑性，进而改善抑郁症患者的临床症状。高压氧疗法作为抗抑郁药物的联合治疗方法，在一定程度上有助于改善治疗效果。 |
| 英文摘要: |
| Hyperbaric oxygen therapy characterized by fewer side effects and simple operation has been explored as a potential therapy for depression. This article provides a review of researches relevant to current clinical application and mechanism of hyperbaric oxygen therapy for depression， aiming to provide valuable references for the formulation of new strategies for the treatment of depression. Hyperbaric oxygen therapy has been demonstrated to be useful as an adjunctive therapy for depression， which can effectively alleviate depression by regulating the homeostasis of hypothalamus-pituitary-adrenal axis， inhibiting inflammation and enhancing synaptic plasticity. And hyperbaric oxygen therapy as adjuvant to antidepressants for depression can contribute to increasing the treatment effectiveness to some extent. |
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