| Background The course of schizophrenia is prolonged, and patients have impaired social function and significantly reduced quality of life. Drug therapy combined with psychological therapy is particularly important for improving the quality of life of patients. Brief cognitive-behavioral therapy (BCBT) has been widely applied in clinical practice, but current research on BCBT focuses more on improving patient symptoms and lacks relevant reports on improving quality of life. Objective To evaluate the effect and influencing factors of BCBT combined with conventional treatment on improving the quality of life in patients with schizophrenia. Methods Select patients who met the diagnostic criteria for schizophrenia in the International Classification of Diseases (10th edition) (ICD-10) and were followed up at the outpatient department of Beijing Anding Hospital affiliated with Capital Medical University from August 2011 to December 2016. Using a random number table method, patients were divided into a study group and a control group, with 105 cases in each group. Both groups received routine treatment, and the research group received a total of 8 BCBT sessions for 12 weeks on this basis. During the baseline period and 12 weeks of treatment, 26 weeks of follow-up, and 52 weeks of follow-up, positive and negative symptom scales (PANSS), individual and social function scales (PSP), and the World Health Organization Quality of Life Scale Brief (WHO QOL-BREF) were used for evaluation. Results The results of repeated measures analysis of variance showed that the time point effect and interaction effect of PANSS total score were statistically significant (F=118.783, 8.083, P<0.01); the time point effect, inter group effect, and interaction effect of PSP total score were statistically significant (F=94.358, 4.048, 5.490, P<0.01 or 0.05); The time point effect, inter group effect, and interaction effect of the total score of the WHOQOL-BREF scale were all statistically significant (F=12.330, 4.168, 4.142, P<0.01 or 0.05), the time point effect and interaction effect of the physiological factor score were all statistically significant (F=6.597, 3.649, P<0.01 or 0.05), the time point effect of the psychological factor score was statistically significant (F=9.909, P<0.01), the time point effect of the social relationship factor score was statistically significant (F=9.451, P<0.01), and the time point effect, intergroup effect, and interaction effect of the environmental factor score were all statistically significant (F=7.486, 6.983, 2.891, P<0.01 or 0.05). Binary logistic regression analysis showed that the study group (OR=1.861、95%CI：1.004~3.448) and young age (OR=1.044、95%CI：1.001~1.088) were protective factors for improving patient quality of life, while high PANSS baseline score (OR=0.972、95%CI：0.945~0.999) was a risk factor for improving patient quality of life. Conclusion The combination of BCBT and conventional treatment has an earlier onset of improvement in the quality of life of patients with schizophrenia, and long-term efficacy is superior to conventional treatment. |