| 林亚男,张梁英,王圆龙,罗欣欣,邵园,王永军.蓝光照射治疗对改善住院阿尔茨海默病患者认知功能的效果[J].四川精神卫生杂志,2024,37(4):302-306.Lin Ya'nan,Zhang Liangying,Wang Yuanlong,Luo Xinxin,Shao Yuan,Wang Yongjun,Efficacy of blue light irradiation in improving cognitive function of inpatients with Alzheimer's disease[J].SICHUAN MENTAL HEALTH,2024,37(4):302-306 |
| 蓝光照射治疗对改善住院阿尔茨海默病患者认知功能的效果 |
| Efficacy of blue light irradiation in improving cognitive function of inpatients with Alzheimer's disease |
| 投稿时间：2024-02-26 |
| DOI：10.11886/scjsws20240226004 |
| 中文关键词: 阿尔茨海默病 光生物调节 蓝光照射 认知功能 |
| 英文关键词:Alzheimer's disease Photobiomodulation Blue light irradiation Cognitive function |
| 基金项目:国家科技部重点研发项目（项目名称：睡眠-认知障碍的精准调控与干预，项目编号：2023YFC3603204）；深圳市康宁医院青年科研项目（项目名称：光生物节律调控在AD治疗中的作用及其机制研究，项目编号：KN2023A004） |
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| 中文摘要: |
| 背景 阿尔茨海默病（AD）是最常见的痴呆类型，发病率逐年上升。药物治疗对改善AD患者认知功能、延缓疾病进展的效果不理想，进而影响治疗依从性。既往基础研究表明，蓝光照射有助于改善AD动物模型的认知功能，但目前缺乏相应关于蓝光照射治疗对AD患者认知功能改善效果的临床研究。目的 探讨蓝光照射治疗对改善AD患者认知功能的效果，以期为改善AD患者的认知功能提供参考。方法 回顾性选取2019年6月—2023年12月于深圳市康宁医院老年科住院治疗的、符合《国际疾病分类（第10版）》（ICD-10）AD诊断标准的患者155例。其中接受蓝光照射联合美金刚射治疗及常规心理治疗的80例为研究组，仅接受美金刚治疗及常规心理治疗的75例为对照组。蓝光照射治疗为期4周、每周5次、每次30 min。于治疗前后，采用简易精神状态评价量表（MMSE）和日常生活能力量表（ADL）进行评定。结果 治疗后，研究组MMSE总评分、定向力、即刻回忆、注意力和计算力、延迟回忆以及语言功能评分均高于治疗前，差异均有统计学意义（Z=-6.931、-5.773、-4.123、-3.649、-3.508、-4.733，P均<0.05），ADL总评分低于治疗前，差异有统计学意义（Z=-7.020，P<0.05）。治疗后，研究组MMSE总评分、定向力、即刻回忆、语言功能评分均高于对照组，差异均有统计学意义（Z=-2.784、-4.621、-2.483、-3.463，P均<0.05），且研究组ADL总评分低于对照组，差异有统计学意义（Z=-3.704，P<0.05）。结论 蓝光照射治疗可能有助于改善AD患者的认知功能和日常生活能力。 |
| 英文摘要: |
| Background Alzheimer's disease （AD） is the most common type of dementia. There has been an increasing trend in incidence rate. The drug therapy has been proven ineffective in improving the cognitive function of AD patients or delaying the disease progression， leading to perceived low adherence with treatment and low efficacy. Previous basic research shows that blue light irradiation is helpful to improve the cognitive function of AD model rats， but there is no corresponding clinical study on the improvement effect of blue light irradiation on cognitive function of AD patients.Objective To explore the efficacy of blue light irradiation in improving the cognitive function of AD patients， so as to provide references for cognitive stabilization or improvement of AD patients.Methods A sample of 155 patients who were hospitalized in Geriatric Department of Shenzhen Kangning Hospital from June 2019 to December 2023 and met the International Classification of Diseases， tenth edition （ICD-10） diagnostic criteria for AD were retrospectively selected. Among them， 80 cases who received blue light irradiation combined with memantine therapy and conventional psychotherapy were the study group， and 75 cases who only received memantine therapy and conventional psychotherapy were the control group. Blue light irradiation therapy lasted for 4 weeks， 5 times per week， with each session lasting for 30 min. Then Mini-Mental State Examination （MMSE） and Activity of Daily Living Scale （ADL） were administered at the baseline and after treatment.Results After treatment， study group reported an increase in MMSE total score， orientation， immediate recall， attention/calculation， delayed recall and language dimension scores （Z=-6.931， -5.773， -4.123， -3.649， -3.508， -4.733， P<0.05）， and a decrease in ADL total score （Z=-7.020， P<0.05） compared to baseline data. Analysis indicated that study group scored higher on MMSE total scale， orientation， immediate recall and language dimensions （Z=-2.784， -4.621， -2.483， -3.463， P<0.05）， and lower on ADL total score （Z=-3.704， P<0.05） than those of control group after treatment.Conclusion Blue light irradiation for AD patients may improve their cognitive function and activities of daily living. ［Fund by National Key Research and Development Project of the Ministry of Science and Technology （number， 2023YFC3603204）； Youth Research Project of Shenzhen Kangning Hospital （number， KN2023A004）］ |
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