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| 无法忍受不确定性与强迫症精神病理的关系及脑神经机制 |
| Relationship between intolerance of uncertainty and obsessive-compulsive disorder pathology and neurobiological mechanisms |
| 投稿时间：2024-06-04 修订日期：2025-07-01 |
| DOI： |
| 中文关键词: 强迫症 无法忍受不确定性 磁共振成像 精神病理 神经机制 |
| 英文关键词:Obsessive-Compulsive Disorder Intolerance of Uncertainty Magnetic Resonance Imaging Psychopathology Neural Mechanisms |
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| 中文摘要: |
| 强迫症（OCD）是一类严重且具有高致残性的精神障碍，影响患者的社会功能及生活质量，并造成沉重的经济负担。无法忍受不确定性（IU）是指对不确定性情境或事件进行感知、解释和反应的认知偏差。本文基于磁共振成像（MRI）技术回顾了IU与强迫症精神病理特征关系的脑神经机制研究进展，探讨了未来可能的研究方向。IU不仅与强迫症患者的认知模式密切相关，而且对强迫症治疗策略具有重要的指导意义。 |
| 英文摘要: |
| Obsessive-compulsive disorder (OCD) is a severe and disabling psychiatric disorder associated with a low quality of life and social functioning of those affected, lead to a heavy economic burden. Intolerance of uncertainty (IU) refers to a cognitive bias in the perception, interpretation, and response to uncertain situations or events. This review discuss the relationship between IU and the psychopathological characteristics of OCD, the progress of brain neuro-mechanism research on their relationship based on magnetic resonance imaging (MRI) technology, and possible directions for future research. IU is not only closely related to the cognitive patterns of OCD patients, but also has important guiding significance for the OCD treatment strategies. |
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