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| 中国人群抑郁症疾病负担的年龄-时期-队列分析 |
| Age-Period-Cohort Analysis of Depression Burden in the Chinese Population |
| 投稿时间：2024-07-20 修订日期：2025-03-22 |
| DOI： |
| 中文关键词: 抑郁症 发病率 疾病负担 年龄-时期-队列模型 |
| 英文关键词:Depressive disorders Incidence Disease Burden Age-period-cohort Model |
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| 中文摘要: |
| 目的 分析1990-2021年中国人群抑郁症流行病学趋势及其变化,为中国人群抑郁症防治措施的制定提供科学依据。方法 通过2021年全球疾病负担数据库获取相关数据,通过联结点回归分析评估中国人群抑郁症的流行病学变化趋势,构建年龄-时期-队列模型,分析发病率和伤残调整寿命年(Disability adjusted life year,DALY)率在年龄、时期以及队列三个因素影响下的趋势变化。结果 2021年中国人群抑郁发病例数4236.02万例,发病率为2345.08/10万,DALY为786.59万人年,DALY率为430.61/10万,其中女性的发病例数、发病率、DALY和DALY率(2645.82万例、2934.55/10万、483.74万人年、533.04/10万)几乎是男性(1590.20万例、1765.37/10万、302.85万人年、330.60/10万)的两倍,发病率和DALY率分别以0.24%和0.27%的速度逐年下降；年龄-时期-队列模型分析结果显示随着年龄增加抑郁症的发病和DALY风险逐渐升高,而出生越早的人群抑郁症的发病和DALY风险越低,而随着时间的推移,抑郁的发病和DALY风险逐渐升高。结论 中国人群正在背负沉重的抑郁症疾病负担,尽管近年来我国抑郁症发病率和DALY率呈现逐年下降的趋势,但是年龄和出生队列因素会加剧抑郁症的发病情况,因此相关部门应尽快制定防治措施以减轻人群的疾病负担。 |
| 英文摘要: |
| Objective To analyze the epidemiological trends of depression and its changes in the Chinese population from 1990 to 2019, and to provide a scientific basis for the development of depression prevention and treatment measures in the Chinese population. Methods Relevant data were obtained from the Global Burden of Disease Database 2021, the epidemiological trend changes were evaluated by linkage point regression analysis, and the age-period-cohort model was constructed to analyze the trend changes of incidence rate and DALY rate under the influence of three factors: age, period, and cohort. Results In 2021, the number of cases of depression in the Chinese population was 42,360,200 cases, with an incidence rate of 23,458,800 per 100,000, and the DALY was 7,865,900 person-years, Among them, the number of cases of depression, incidence rate, DALY and DALY rate of women (26,458,200 cases, 29,345,500 per 100,000, 4,837,400 person-years, 533. 04/100,000) was almost twice that of men (1590.20 million cases, 17.6537/100,000, 3.028,500 person-years, 3.360/100,000), and the incidence rate and DALY rate decreased by 0.24% and 0. 27%, respectively; the results of the analysis of the age-period-cohort model showed that the incidence of depression and the DALY with increasing age The risk of depression and DALY gradually increased with age, while the earlier the birth, the lower the risk of depression and DALY, and the risk of depression and DALY gradually increased with time. Conclusion The Chinese population carries a heavy burden of depression, and although the incidence and DALY rates have been decreasing year by year in recent years, age and birth cohort factors may exacerbate the incidence of depression, and therefore the relevant authorities should formulate preventive and curative measures as soon as possible to alleviate the burden of the disease in the population. |
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