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| 孕中晚期抑郁孕妇的功能近红外光谱成像特征 |
| Functional near-infrared spectroscopy characteristics of depressed pregnant women in mid-to-late pregnancy |
| 投稿时间：2024-12-03 修订日期：2025-05-15 |
| DOI： |
| 中文关键词: 孕产妇 抑郁 功能近红外光谱成像 |
| 英文关键词:Maternal Depression Functional near-infrared spectroscopy |
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| 中文摘要: |
| 背景 围产期抑郁症对产妇及后代有着巨大的影响。孕中晚期抑郁尤其明显,目前关于孕中晚期抑郁孕妇的近红外光谱功能成像特征研究有限。目的 分析孕中晚期抑郁孕妇的功能近红外光谱成像特征,有助于临床孕中晚期抑郁筛查。方法 从2023年9月至2024年7月,采用随机分层抽样,于绵阳市第三人民医院纳入了80名孕中晚期孕妇作为研究对象。用自编一般问卷采集孕妇基本信息。用功能近红外光谱成像仪器测量了孕妇在语言流畅性任务(verbal fluency task, VFT)期间前额叶、颞叶的积分值S与重心值T。用偏相关分析了孕周、EPDS评分与前额叶积分值S相关性。用线性回归分析了抑郁评分(EPDS score)与前额叶积分值S的关系。结果 抑郁组孕妇在孕晚期(28-38周)、意外怀孕的比例明显高于对照组,差异具有统计学意义(χ2=8.498、7.040,P＜0.01)。抑郁组孕妇的前额叶积分值S明显小于对照组,差异具有统计学意义(t=-5.416,P＜0.01),而两组前额叶重心值T、双侧颞叶积分值S、双侧颞叶重心值T差异不具有统计学意义。EPDS评分与前额叶积分值S呈负相关(β=-4.503,P＜0.01,r2=0.126)。结论 处于孕晚期、意外怀孕可能更易发生抑郁。孕中晚期抑郁孕妇较非抑郁孕妇前额叶激活程度更低,且前额叶激活程度与抑郁水平呈负相关。 |
| 英文摘要: |
| Background Perinatal depression has a huge impact on the mother and offspring. Depression is particularly pronounced in mid- and late pregnancy, and there is limited research on functional near-infrared spectroscopy characterization of pregnant women with mid- and late-pregnancy depression. Objettive Analysis of functional near-infrared spectroscopic features in pregnant women with mid- to late-pregnancy depression to assist clinical screening for mid- to late-pregnancy depression. Methods From September 2023 to July 2024, 80 pregnant women with mid- to late-pregnancy depression were enrolled in the Third Hospital of Mianyang City using random stratified sampling. A self-administered general questionnaire was used to collect basic information about the pregnant women. Functional near-infrared spectroscopic imaging was used to measure the prefrontal and temporal lobe scores S and center of gravity T during the verbal fluency task (VFT), and the correlation between week of gestation, EPDS scores, and prefrontal lobe score S was analyzed by partial correlation. Linear regression was used to analyze the relationship between depression score (EPDS score) and prefrontal lobe integral value S. Results The proportion of pregnant women in the depressed group in late pregnancy (28-38 weeks) and unplanned pregnancy was significantly higher than that of the control group, and the difference was statistically significant (χ2=8.498, 7.040, P<0.01). The prefrontal lobe integral value S of pregnant women in the depressed group was significantly smaller than that of the control group, and the difference was statistically significant (t=-5.416, P<0.01), whereas the differences between the two groups in prefrontal center of gravity value T, bilateral temporal lobe integral value S, and bilateral temporal lobe center of gravity value T were not statistically significant. Depression level was negatively correlated with prefrontal lobe integral value S (β=-4.503, P<0.01, r2=0.126). Conclusion Depression may be more likely to occur in late pregnancy and in unplanned pregnancies. Depressed pregnant women in mid- to late-pregnancy have lower prefrontal activation than non-depressed pregnant women, and prefrontal activation is negatively correlated with depression levels. |
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