| 崔迎奥,杨铖,田英汉,申晴晴,刘寰忠.首发和复发精神分裂症患者新型炎症指标水平与攻击性的关系[J].四川精神卫生杂志,2025,38(1):28-33.Cui Ying'ao,Yang Cheng,Tian Yinghan,Shen Qingqing,Liu Huanzhong,Relationship between levels of novel inflammatory indicators and aggressivity in patients with first-episode and recurrent schizophrenia[J].SICHUAN MENTAL HEALTH,2025,38(1):28-33 |
| 首发和复发精神分裂症患者新型炎症指标水平与攻击性的关系 |
| Relationship between levels of novel inflammatory indicators and aggressivity in patients with first-episode and recurrent schizophrenia |
| 投稿时间：2024-05-06 |
| DOI：10.11886/scjsws20240506002 |
| 中文关键词: 精神分裂症 首发 复发 新型炎症指标 攻击性 |
| 英文关键词:Schizophrenia First-episode Recurrent Novel inflammatory indicators Aggressivity |
| 基金项目:安徽省自然科学基金项目（项目名称：基于GSK-3β/NF-kB信号通路对氯氮平所致代谢综合征的机制研究，项目编号：2108085MH275） |
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| 中文摘要: |
| 背景 精神分裂症患者的攻击行为可能会引发法律纠纷和公共安全问题。不同疾病发作次数的患者新型炎症指标水平与攻击性之间的关系可能存在差异。目的 探讨首发和复发精神分裂症患者新型炎症指标水平与攻击性相关性的差异，寻找评定精神分裂症患者攻击性水平的炎症标志物。方法 选取2022年10月—2024年4月因急性发病在安徽医科大学附属巢湖医院住院的、符合《精神障碍诊断与统计手册（第5版）》（DSM-5）诊断标准的168例精神分裂症患者为研究对象，其中，首发组58例，复发组110例。同期在社区招募与患者组年龄和性别相匹配的110名健康被试作为对照组。所有患者均接受修订版外显攻击行为量表（MOAS）以及阳性和阴性症状量表（PANSS）评定。检测所有受试者新型炎症指标水平，包括中性粒细胞与淋巴细胞比值（NLR）、单核细胞与淋巴细胞比值（MLR）、血小板与淋巴细胞比值（PLR）、中性粒细胞与高密度脂蛋白比值（NHR）、单核细胞与高密度脂蛋白比值（MHR）以及血小板与高密度脂蛋白比值（PHR）。采用Spearman相关分析考查首发和复发精神分裂症患者新型炎症指标水平与MOAS总评分的相关性。结果 首发组NLR、MLR、PLR、NHR、MHR、PHR水平均高于对照组，差异均有统计学意义（调整后P均<0.01）；复发组NLR、MLR、NHR、MHR、PHR水平均高于对照组，差异均有统计学意义（调整后P均<0.01）；首发组与复发组六个新型炎症指标水平比较，差异均无统计学意义（调整后P均>0.05）。Spearman相关分析结果显示，复发组MOAS总评分与NLR、MLR、PLR水平均呈正相关（r=0.234、0.192、0.243，P均<0.05），首发组MOAS总评分与六个新型炎症指标水平的相关性均无统计学意义（P均>0.05）。结论 首发和复发精神分裂症患者新型炎症指标水平与攻击性的相关性可能存在差异。NLR、MLR、PLR可能是评定复发精神分裂症患者攻击性水平的炎症标志物。 |
| 英文摘要: |
| Background Aggressive behavior in schizophrenic patients could result in legal disputes and public safety concerns. In patients with illness episodes of different numbers， there may exist differences in the association between levels of novel inflammatory indicators and aggressivity.Objective To investigate the differences in the correlation between levels of novel inflammatory indicators and aggressivity in patients with first-episode and recurrent schizophrenia， in order to search for inflammatory biomarkers to assess aggression level in schizophrenic patients.Methods A total of 168 schizophrenic patients were selected as subjects， who were hospitalized for acute disease onset in Chaohu Hospital of Anhui Medical University from October 2022 to April 2024 as well as met the diagnostic criteria of Diagnostic and Statistical Manual of Mental Disorders， fifth edition （DSM-5）. Patients were divided into first-episode group （n=58） and recurrent group （n=110）. Meanwhile， 110 healthy controls from community who matched in age and gender with the patient group were recruited. All patients were evaluated with Modified Overt Aggression Scale （MOAS） and Positive and Negative Syndrome Scale （PANSS）. All subjects went through examination of the levels of novel inflammatory indicators， including neutrophil/lymphocyte ratio （NLR）， monocyte/lymphocyte ratio （MLR）， platelet/lymphocyte ratio （PLR）， neutrophil/high-density lipoprotein ratio （NHR）， monocyte/high-density lipoprotein ratio （MHR） and platelet/high-density lipoprotein ratio （PHR）. Spearman correlation analysis was adopted to investigate the correlation between levels of novel inflammatory indicators and the total score of MOAS in patients with first-episode and recurrent schizophrenia.Results The levels of NLR， MLR， PLR， NHR， MHR and PHR in first-episode group were higher than those in control group （adjusted P<0.01）. The levels of NLR， MLR， NHR， MHR and PHR in recurrent group were higher than those in control group （adjusted P<0.01）. No significant difference was observed in the comparison in the levels of six novel inflammatory indicators between first-episode group and recurrent group （adjusted P>0.05）. Spearman correlation analysis showed， the MOAS total score of recurrent group was positively correlated with the levels of NLR， MLR and PLR （r=0.234， 0.192， 0.243， P<0.05）. There was no statistical significance in the correlation between MOAS total score and levels of six novel inflammatory indicators in first-episode group （P>0.05）.Conclusion Among patients with first-episode and recurrent schizophrenia， the correlation between levels of novel inflammatory indicators and aggressivity could differ. NLR， MLR and PLR might be the biomarkers for assessing aggression level in recurrent schizophrenic patients. ［Funded by Anhui Provincial Natural Science Foundation （number， 2108085MH275）］ |
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