李迎寅,杨鹏,王美洁,时亚杰,李燕飞,李坤,张校明.精神障碍患者改良电休克治疗的初始癫痫发作阈值的相关因素分析[J].四川精神卫生杂志,2025,(4):302-307.Li Yingyin,Yang Peng,Wang Meijie,Shi Yajie,Li Yanfei,Li Kun,Zhang Xiaoming,Analysis of factors correlating with the initial seizure threshold in modified electroconvulsive therapy for patients with mental disorders[J].SICHUAN MENTAL HEALTH,2025,(4):302-307
精神障碍患者改良电休克治疗的初始癫痫发作阈值的相关因素分析
Analysis of factors correlating with the initial seizure threshold in modified electroconvulsive therapy for patients with mental disorders
投稿时间:2024-11-01  
DOI:10.11886/scjsws20241101001
中文关键词:  改良电休克治疗  精神障碍  初始癫痫发作阈值  影响因素
英文关键词:Modified electroconvulsive therapy  Mental disorders  Initial seizure threshold  Influencing factor
基金项目:2024年济宁市重点研发计划项目(项目名称:精神障碍患者行无抽搐电休克治疗(MECT)首次能量阈值选择的预测研究,项目编号:2024YXNS202)
作者单位邮编
李迎寅 济宁医学院山东 济宁 272051
山东省戴庄医院山东 济宁 272051 
272051
杨鹏 山东省戴庄医院山东 济宁 272051 272051
王美洁 山东省戴庄医院山东 济宁 272051 272051
时亚杰 山东省戴庄医院山东 济宁 272051 272051
李燕飞 山东省戴庄医院山东 济宁 272051 272051
李坤 山东省戴庄医院山东 济宁 272051 272051
张校明* 山东省戴庄医院山东 济宁 272051 272051
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中文摘要:
      背景 改良电休克治疗(MECT)是目前广泛应用于精神科临床一线的一种物理治疗方法,临床上通常根据患者初始癫痫发作阈值(IST)的影响因素对MECT首次最佳刺激剂量进行估计。然而,既往关于IST影响因素的研究存在样本量较小、研究维度单一等不足。目的 探索精神障碍患者IST的影响因素,以期为精神障碍患者MECT的IST量化选择提供参考。方法 采用回顾性研究,纳入2021年1月1日—2023年8月1日在山东省戴庄医院住院治疗的、符合《国际疾病分类(第10版)》(ICD-10)任一精神障碍诊断标准且接受MECT治疗的患者1 446例,收集其一般资料及临床资料,包括IST、诊断类别、性别、民族、年龄、体质量、体质量指数(BMI)、病程、精神疾病家族史、是否首发、治疗前一天是否服用抗癫痫药物、治疗前一天是否服用苯二氮?类药物以及是否有MECT治疗史。采用Pearson相关分析检验患者IST与年龄、身高、体质量、BMI、病程的相关性;采用多元线性逐步回归分析考查患者IST的影响因素。结果 ①不同性别、是否首发、治疗前一天是否服用抗癫痫药物、治疗前一天是否服用苯二氮?类药物的患者IST比较,差异均有统计学意义(t=2.256、-3.059、-2.136、-3.006,P<0.05或0.01);不同年龄段、不同诊断类别的患者IST比较,差异均有统计学意义(F=913.120、6.212,P均<0.01)。②在青年人群中,不同诊断类别的患者IST比较,差异有统计学意义(F=2.986,P<0.05)。③相关分析结果显示,患者的IST与年龄、体质量、BMI、病程均呈正相关(r=0.886、0.055、0.184、0.456,P<0.05或0.01),与身高呈负相关(r=-0.183,P<0.01)。④多元线性逐步回归分析结果显示,年龄、性别、体质量是IST的影响因素(β=0.888、-0.049、-0.035,P均<0.01)。结论 年龄、性别、体质量可能是精神障碍患者IST的影响因素。
英文摘要:
      Background Modified electroconvulsive therapy (MECT) is a common front-line strategy widely used in psychiatric practice, and the optimal first stimulus dosage in MECT is usually estimated clinically based on the factors influencing the patient's initial seizure threshold (IST). However, previous studies on the influencing factors of IST have mostly suffered from limitations such as small sample sizes and single-dimensional research perspectives.Objective To explore the factors influencing IST in MECT for patients with mental disorders, so as to provide references for stimulus dosing strategies in MECT for the patients.Methods A retrospective study was used to include 1 446 inpatients fulfilling the diagnostic criteria for any specific mental disorder listed in the ICD-10 and receiving MECT at Shandong Daizhuang Hospital from January 1, 2021 to August 1, 2023. Their general and clinical data were collected, including IST, psychiatric diagnostic categories, gender, ethnicity, age, body weight, body mass index (BMI), course of disease, family history of psychiatric disorders, first episode status, use of antiepileptic drugs the day before treatment, use of benzodiazepines the day before treatment, and previous MECT treatment history. Pearson correlation analysis was utilized to test the correlation of IST with age, height, body weight, BMI, and course of disease, and stepwise multivariate linear regression analysis was performed to identify the factors affecting IST.Results IST yielded statistical difference among patients in terms of gender, first episode status, use of antiepileptic drugs the day before treatment, and use of benzodiazepines the day before treatment (t=2.256, -3.059, -2.136, -3.006, P<0.05 or 0.01). IST in patients of different ages and psychiatric diagnostic categories also demonstrated statistical difference (F=913.120, 6.212, P<0.01). Within young population, IST varied significantly based on the psychiatric diagnostic categories (F=2.986, P<0.05). Correlation analysis indicated that IST was positively correlated with age, body weight, BMI and course of disease (r=0.886, 0.055, 0.184, 0.456, P<0.05 or 0.01), and negatively correlated with height (r=-0.183, P<0.01). Stepwise multivariate linear regression analysis revealed that age, gender, and body weight were influencing factors of IST (β=0.888, -0.049, -0.035, P<0.01).Conclusions Age, gender and body weight may be factors influencing IST in MECT for patients with mental disorders. [Funded by Key R&D Plan Projects of Jining City in 2024 (number, 2024YXNS202)]
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