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| 绵阳地区中老年尿液阿尔茨海默相关神经丝蛋白水平及相关因素分析 |
| Analysis of urine Alzheimer- associated neuronal thread protein level and related factors in Mianyang Sichuan Middle-aged Men |
| 投稿时间：2022-05-04 修订日期：2023-02-27 |
| DOI： |
| 中文关键词: AD7c-NTP 阿尔茨海默病 尿液 尿酸 |
| 英文关键词:AD7c-NTP Alzheimer"s disease Urine Uric acid |
| 基金项目:1. 四川省卫生和计划委员会科研课题(项目名称：尿阿尔茨海默相关神经丝蛋白(AD7C-NTP)和血清胰岛素联合检测在阿尔茨海默病临床诊断中的应用价值；项目编号16PJ402)；2. 绵阳市卫健委科研课题（项目名称：绵阳地区健康成年人群尿液AD7c-NTP参考区间的建立；项目编号202018; 3.国家自然科学基金青年基金 （项目名称：TRPC1介导海马内少突胶质细胞与有髓神经纤维损伤对糖尿病认知功能障碍作用的机制探讨；项目编号81400806） |
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| 中文摘要: |
| 目的 探讨尿液阿尔茨海默相关神经丝蛋白(Alzheimer- associated neuronal thread protein, AD7c-NTP)在体检人群的分布及常见代谢性指标与其含量的相关性。方法 选取四川省科学城医院与绵阳市第三人民医院体检者1150例,采用酶联免疫吸附法检测尿AD7c-NTP,常规方法测定血生化指标。收集体检者人口学指标和神经系统相关检查。结果 体检者尿液AD7c-NTP浓度中位值0.60 (0.30,1.20) ng/ml,男0.84 ng/ml,女1.04 ng/ml,最高9.10 ng/ml,女性高于男性,差异有统计学意义(z =4.202,P＜0.01)。＜1.5ng/ml者956例,中位值0.50(0.30,0.90)；≥1.5ng/ml者194例,中位值2.10(1.70,2.10)；尿液AD7c-NTP浓度除与年龄(r=0.184, P＜0.01,Y=-0.1871+0.01663X)外,与其它人口学指标及相关神经系统疾病等无相关性；AD7c-NTP正常组和升高组的血糖 (t/z =3.506, P＜0.01)、血尿酸 (t/z =2.574, P＜0.05)、血尿素氮 (t/z =2.891, P＜0.05)、总胆红素(t/z =3.936, P＜0.01)、谷草转氨酶(t/z =0.969, P＜0.05)、总胆固醇(t=3.956, P＜0.01)、低密度脂蛋白(t/z =-5.678, P＜0.01)差异有统计学意义；女性(n=556)尿AD7c-NTP与血UA值相关性具统计学意义(r=0.148,P＜0.01,Y=0.09313+0.003098X),男性未观察到。结论 尿AD7c-NTP值与年龄相关,女性尿AD7c-NTP值和血尿酸水平相关,预防认知功能障碍,早发现阿尔茨海默病,需加强血尿酸值监控。 |
| 英文摘要: |
| Objective To investigate the distribution of Alzheimer-associated neurofilament protein (Alzheimer-associated neuronal thread protein, AD7c-NTP) in urine of physical examination population and the correlation between common metabolites and urine AD7c-NTP content. Methods A total of 1150 physical examination patients were enrolled from the Physical Examination Center of Science City Hospital and the Third Hospital Of Mianyang ,Sichuan Province. The urinary AD7c-NTP were measured by enzyme-linked immunosorbent assay (ELISA), and common metabolites in blood were measured by biochemical analyzer routinely. Results The median of urinary AD7c-NTP level in physical examination patients was 0.60 (0.30, 1.20) ng/ml, There was significant difference in the highest AD7c-NTP concentration between male and female (z =4.202,P＜0.01), female were higher than male. 956 cases with <1.5ng/ml, median 0.50(0.30,0.90), 194 cases with ≥ 1.5ng/ml, median 2.10(1.70,2.10) ; Urine AD7c-NTP concentration was not correlated with other demographic indexes and related nervous system diseases, except for age (r ≥ 0.184, P < 0.01, Y=-0.1871+ 0.01663X). There were significant differences in blood glucose (t/z = 3.506, P＜0.01), serum uric acid ( t/z=2.574, P＜0.01), blood urea nitrogen (t/z = 2.891, P＜0.01), Total Bilirubin total (t/z =3.956, P＜0.01),Aspartate aminotransferase (t/z =0.969, P＜0.05),cholesterol (t =3.956, P＜0.01) and low density lipoprotein (t =-5.678, P＜0.01) between normal and elevated groups. The correlation between urinary AD7c-NTP and blood UA was statistically significant in women (r=0.148, P<0.01, Y=0.09313 +0.003098X), but not observed in males. Conclusion Urine AD7c-NTP value is related to age, female urine AD7c-NTP value is related to serum uric acid level, prevention of cognitive impairment, early detection of Alzheimer-associated disease, it is necessary to strengthen the monitoring of blood uric acid value. |
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