| Background People with schizophrenia is the high risk population of metabolic syndrome. Previous studies on the influencing factors of metabolic syndrome mainly focused on the inpatients, with limited researches on patients living in community. Objective To explore the influencing factors among different risk levels of metabolic syndrome in community patients with schizophrenia in Guangzhou and provide references for future interventions on metabolic syndrome in community schizophrenia patients. Methods A total of 3 339 patients with schizophrenia who were registered in Guangzhou Mental Health Information System and finished the physical examination in 2020 were included in the study. Patients’ physical examination data were extracted from this system and whether these patients had metabolic syndrome was assessed based on the the standard diagnosis of Chinese Diabetes Society. Patients were divided into high-risk group (n=423), critical group (n=1 524) and metabolic syndrome group (n=1 392) according to the Chinese expert consensus on the management of metabolic syndrome in patients with schizophrenia. Univariate analysis and multiple logistic regression were used to analyze the risk factors of metabolic syndrome in patients with schizophrenia. Results The prevalence rate of metabolic syndrome was 41.69% in community patients with schizophrenia. Univariate analysis showed that sex (χ2=44.610), age (χ2=55.992), marriage status (χ2=30.755), illness duration (χ2=25.913) and body mass index (χ2=829.265) were significantly different among the three groups (P＜0.01). Kruskal-Wallis H analysis showed the levels of waist circumference (H=920.331), systolic blood pressure (H=436.673), diastolic blood pressure (H=393.337), fasting blood glucose (H=807.304), triglyceride (H=1 134.125) and high density lipoprotein cholesterol (H=593.615) among the three groups were significantly different (P＜0.01). Logistic regression showed that age greater than or equal to 50 years old (OR=1.761, 95% CI: 1.087~2.853), overweight (OR=2.418, 95% CI: 1.862~3.140) and obesity (OR=57.903, 95% CI: 14.340~233.802) were risk factors for high risk patients becoming critical population (P<0.05 or 0.01). Female (OR=1.295, 95% CI: 1.034~1.622), age between 40 to 49 years old (OR=2.597, 95% CI: 1.582~4.263), age greater than or equal to 50 years old (OR=4.392, 95% CI: 2.609~7.395), overweight (OR=7.844, 95% CI: 6.018~10.223) and obesity (OR=426.785, 95% CI: 105.724~1 722.839) were risk factors for high risk patients developing into metabolic syndrome population (P<0.05 or 0.01). Conclusion The prevalence rate of metabolic syndrome is higher in community patients with schizophrenia. Patients who were female, older, overweight and obesity have a higher risk to stay with metabolic syndrome. [Funded by Health Science and Technology Project in Guangzhou (number, 20221A010028)] |