| LIU Fang,ZHANG Bing- kui,XIE Li-qin,A double-blind, randomized, controlled trial of minocycline combined with risperidone in the treatment of negative symptoms in early-phase schizophrenia[J].SICHUAN MENTAL HEALTH,2014,27(1):30-32 |
| A double-blind, randomized, controlled trial of minocycline combined with risperidone in the treatment of negative symptoms in early-phase schizophrenia |
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| English keywords:Schizophrenia Negative symptom Minocycline |
| Fund projects:国家卫生部行业专项基金（201002003）;国家自然科学基金项目（81071093、30900485和81270019）;国家科技部科技重大专项“重大新药创制”（2012ZX09303014-001） |
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| Objective Exploring the efficacy of minocycline combining with risperidone in the treatment of negative symptom of early - phase schizophrenia. Methods Ninety - two patients with early stage schizophrenia treated with risperidone were randomly as- signed to receive minoeycline or placebo. Two treatment group both take 16 - weeks. The clinical effect and adverse reactions were as- sessed with the Scale for the Assessment of Negative Symptoms （SANS） , the Positive and Negative Syndrome Scale （PANSS）, Barnes Akathisia Scale （Barnes） and Simpson Extrapyramidal Rating Scale （SAS） before the treatment and after. Results Subjects receiv- ing minocycline had greater improvements on SANS total scores, PANSS negative subscale scores and PANSS total score （ P 〈 0.01 ） when compared with those receiving placebo. Conclusion The addition of minocycline to atypical antipsychoticdrugs in early schizo- phrenia had significant efficacy on negative symptoms and had no serious side effect in patients with schizophrenia. |
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