| LIU Fang,XIE Li-qin,ZHANG Bing-kui,A double-blind,randomized,controlled trial of minocycline combined with risperidone in the treatment of negative symptoms in early-phase schizophrenia[J].SICHUAN MENTAL HEALTH,2014,27(2):128-131 |
| A double-blind,randomized,controlled trial of minocycline combined with risperidone in the treatment of negative symptoms in early-phase schizophrenia |
DOI：10.11886/scjsws201402011 |
| English keywords:Schizophrenia Negative symptom Minocycline Cytokine |
| Fund projects:国家卫生部行业专项基金（201002003）;国家自然科学基金项目（81071093、30900485和81270019）;国家科技部科技重大专项“重大新药创制”（2012ZX09303014-001） |
|
| Hits: |
| Download times: |
| English abstract: |
| Objective Our study explore the efficacy and mechanism of minocycline combining with risperidone in the treatment of negative symptom in early-phase schizophrenia.Methods Ninety-two patients with early stage schizophrenia treated with risperidone were randomly assigned to receive minocycline or placebo.Two treatment group both take 1 6-weeks.The clinical effectand immune factor were assessed with the Scale for the Assessment of Negative Symptoms （SANS）,the Positive and Negative Syndrome Scale （PANSS）,concentration of IL-1β,TNF-α,NObefore the treatment and the end.Results Sub-jects receiving minocycline had greater improvements on PANSS negative subscale scores and PANSS total score （P〈0.01） when compared with those receiving placebo.Minocycline have no effect on the concentration of IL-1β,TNF-αexcept for NO.Conclusion The addition of minocycline to atypical antipsychoticdrugs in early schizophrenia had significant efficacy on neg-ative symptoms.The mechanism is still unknown and is speculated to be related to inhibited the concentration of NO |
| View Full Text
View/Add Comment Download reader |
| Close |