| WANG Zhi-qiang,WEN Lu,REN Zin,Meta-analysis of clinical effects and switching rate of lamotrigine and antidepressants in treatment of bipolar depression[J].SICHUAN MENTAL HEALTH,2015,28(1):11-13 |
| Meta-analysis of clinical effects and switching rate of lamotrigine and antidepressants in treatment of bipolar depression |
DOI：10.11886/j.issn.1007-3256.2015.01.004 |
| English keywords:Lamortigne Antidepressant Bipolar depression Meta-analysis |
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| Objective To assess the difference in therapy efficacy and safety between lamotrigine adding antidepressants and sin-gle antidepressant in treatment of bipolar depression. Methods studies meeting our criteria were analyzed by based-evidence medi-cine,comparing the difference in symptoms changes,efficacy rate,and switching rate. Results The decreasing of symptoms scale in combined group was more significant than that of single antidepressant( WMD= -1. 81,95%CI:-2. 64 ~ -1. 71,Z=5. 52,P<0. 01),and effective rate in combined group was more higher than that of single antidepressants(59/109 vs 35/106,OR=2. 43,95%CI:1. 38~ 4. 27,Z=3. 08,P<0. 01),And switching rate in combined group was more lower than that of single antidepressants(7/86vs. 21/85,OR=0. 2,95%CI=0. 10 -0. 66,Z=2. 86,P<0. 01). Conclusion Lamotrigine adding antidepressant may promote treating efficacy,and decrease switching. |
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