| XIE Zhi-bing,LIANG Mei-ling,Cognitive P300 and P50 sensory gating characteristics of patients with anxiety disorders[J].SICHUAN MENTAL HEALTH,2015,28(1):25-27 |
| Cognitive P300 and P50 sensory gating characteristics of patients with anxiety disorders |
DOI：10.11886/j.issn.1007-3256.2015.01.008 |
| English keywords:Anxiety disorders Cognitive potential P300 Sensory gating potential P50 |
| Fund projects:珠海市慢性病防治中心精神卫生科 |
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| Objective To explore the characteristics of cognitive potential P300 and sensory gating P50 in patients with anxiety. Methods From 2014 January to October,a total of 67 patients met the diagnosis of anxiety disorder of CCMD-3 in Zhuhai chronic disease prevention and control center of psychological outpatient clinic were selected. Hamilton Anxiety Rating Scale-14 items( HA-MA-14)was used to assess the disease severity. And cognitive potentials P300 and Sensory gating potential P50 detection were com-pared with 40 normal persons( control group). Results ①The P300 latency of the anxiety group was longer than the control group [(378. 26 ± 53. 47)ms vs.(332. 65 ± 37. 78)ms,(P<0. 01)]. ②The P50 suppression ratio(S2/S1 amplitude ratio)of the anxiety group was higher than that of the control group[(89 ± 41)%vs.(55 ± 20)%,P<0. 01]. Conclusion Compared with the normal , patients with anxiety disorder were significantly prolonged the latency of P300 ,significantly impaired cognitive func-tion. Auditory sensory gating potential P50 inhibitory existing defects,and can not effectively filtering irrelevant in-formation. Detection of P300 and P50 could be screening patients with anxiety disorder auxiliary index of early cog-nitive impairment. |
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