| ,Association between the polymorphism of 5 - hydroxy tryptamineta 1B receptor gene and impulsive aggression behavior in patients with comorbid alcohol dependency and bipolar disorder[J].SICHUAN MENTAL HEALTH,2019,32(1):29-32 |
| Association between the polymorphism of 5 - hydroxy tryptamineta 1B receptor gene and impulsive aggression behavior in patients with comorbid alcohol dependency and bipolar disorder |
DOI：10.11886/j.issn.1007-3256.2019.01.005 |
| English keywords:Bipolar disorder Impulsive aggression behavior 5 - hydroxy tryptamine receptor |
| Fund projects:新疆维吾尔自治区自然科学基金（2013211A107） |
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| Objective To investigate the correlation between impulsive aggression behavior and 5 - hydroxy tryptamine 1 B receptor ( 5 - HTR1 B ) gene polymorphisms in patients with comorbid alcohol dependency and bipolar disorder, and to provide references for understanding the potential genetic differences in the mechanism of pathophysiological changes caused by impulsive aggression of patients with comorbid alcohol dependency and bipolar disorder. Methods A total of 230 patients who were diagnosis with alcohol dependency cormobid with bipolar disorder according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition( DSM - IV) were recruited. All patients were divided into the impulsive aggression group ( n = 128 ) and non - impulsive aggressive behavior group ( n = 102) according to the Modified Overt Aggression Scale ( MOAS) score. The polymorphisms of rs6296 were identified by PCR direct sequencing, in addition the relationship between the differences of 5 - HTR1 B rs6296 polymorphisms and impulsive aggression were analyzed. Results There was no significant difference between the genotype of rs6296 in the impulsive aggression group( n = 128) and the non - impulsive aggressive behavior group( χ2 = 2. 135, P > 0. 05) . No significant difference was found between the allele frequency of rs6296 in the two groups ( χ2 = 2. 771 , P > 0. 05) . Conclusion There was no correlation between impulsive aggression behavior and 5 - HTR1B rs6296 polymorphisms in patients with comorbid alcohol dependency and bipolar disorder. |
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