| ,Effects of venlafaxine extended release capsules combined with MECT on efficacy and cognitive function in moderate and severe depression episode[J].SICHUAN MENTAL HEALTH,2019,32(1):38-41 |
| Effects of venlafaxine extended release capsules combined with MECT on efficacy and cognitive function in moderate and severe depression episode |
DOI：10.11886/j.issn.1007-3256.2019.01.007 |
| English keywords:Modified Electroconvulsive Therapy Depressive episode Efficacy Cognitive function |
| Fund projects:北京市科学技术委员会“ 首都特色临床应用研究”专项资助课题(Z161100000516047) |
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| Objective To compare the effects of venlafaxine extended release capsules combined with modified electroconvulsive therapy ( MECT) and venlafaxine sustained - release capsules alone on the efficacy and cognitive function of moderate to severe depressive episode. Methods 160 patients who met the diagnostic criteria of International Classification of Diseases, tenth edition ( ICD - 10) for depressive episode were enrolled in this study. According to the random number table, they were divided into the venlafaxine extended release capsules combined with MECT group ( the research group) and the venlafaxine extended release capsules alone ( the control group) with 80 subjects in each group. The initial dose of venlafaxine in both groups was 75 mg /d, and the dosage could be increased to 225 mg /d depending on the patient's disease status and tolerance. At the same time, the research group received 8 times MECT in total. At the 1st week, they received MECT once a day for 5 consecutive treatments. At the 2nd week of treatment, patients received MECT once every other day for a total of 3 times. The study period was 4 weeks. The depressive symptoms were assessed with Hamilton Depression Scale - 17 item ( HAMD - 17) at the baseline and the 2nd, 4th week of treatment. The cognitive function was assessed with Wisconsin Card Sorting Test ( WCST) only in study group. Results At the 2nd, 4th week of treatment, HAMD - 17 scores of both groups were lower than those before treatment ( t = 2. 846 ~ 9. 803, P < 0. 01 ) . At the end of the 2nd week, HAMD - 17 score of the study group was lower than that of the control group ( t = 2. 070, P < 0. 05 ) . The total response number, completion classification, error response number, conceptualization, non - persistent error and learning to learn scores of WCST in the study group were higher at the end of the 2nd week than before treatment ( t = 2. 099 ~ 2. 257, P < 0. 05) and the 4th week of treatment ( t = 1. 997 ~ 2. 257, P < 0. 05) . Conclusion The effect of venlafaxine extended release capsules combined with MECT is better than that of venlafaxine extended release capsules alone on moderate to severe depressive episode. The short - term and reversible cognitive function changes are observed in patients in the combination group. |
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