| ,Research progress on neurotrophic factor hypothesis and the pathogenesis of depressive disorder[J].SICHUAN MENTAL HEALTH,2019,32(1):81-85 |
| Research progress on neurotrophic factor hypothesis and the pathogenesis of depressive disorder |
DOI：10.11886/j.issn.1007-3256.2019.01.019 |
| English keywords:Depression BDNF proBDNF mBDNF tPA |
| Fund projects:云南省科技厅－昆明医科大学应用基础研究联合专项项目[2017FE467(-152)] |
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| So far, the researches on the neurotrophic factor hypothesis of the pathogenesis of depression is not clear. Current research focuses more on the role of Brain - derived Neurotrophic Factor ( BDNF) and its precursor ( proBDNF) as well as maturation ( mBDNF) in depressive disorder. The researches indicate that the level of proBDNF protein increased while mBDNF protein level decreased in patients with depression. With deepening of the researches on neurotrophic factor hypothesis, it has been found that the tissue - type Plasminogen Activator ( tPA) can alleviate the symptoms of depression by promoting the translation of proBDNF into mBDNF, the Plasminogen Activator Inhibitor - 1 ( PAI - 1 ) can inhibit the expression of tPA, the expression of PAI - 1 in patients with depression increased. In this article, the relationship among BDNF, proBDNF, mBDNF, tPA and PAI - 1 with depression were reviewed, so as to provide references for the pathogenesis, diagnosis and treatment of depressive disorder. |
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