| ,White matter integrity in patients with bipolar Ⅰ disorder:a whole brain fractional anisotropy study[J].SICHUAN MENTAL HEALTH,2019,32(2):116-119 |
| White matter integrity in patients with bipolar Ⅰ disorder:a whole brain fractional anisotropy study |
DOI：10.11886/j.issn.1007-3256.2019.02.005 |
| English keywords:Bipolar disorder Magnetic resonance imaging Voxel - based analysis Fractional anisotropy White matter |
| Fund projects:国际自然科学基金（81171287） |
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| Objective To compare white matter fractional anisotropy ( FA) between bipolar I disorder patients and healthy controls, in order to explore the white matter integrity of bipolar I patients. Methods During January 2012 to July 2014, 22 patients meeting Diagnostic and Statistical Manual of Mental Disorders, fourth edition ( DSM - IV) criteria for bipolar I disorder were enrolled from the Second Xiangya Hospital of Central South University. During the same period, 24 healthy individuals which match on the gender, age and education were randomly enrolled from surrounding communities as healthy controls. All subjects underwent 3. 0Tmagnetic resonance imaging scan to obtain white matter structural data. Subsequently, FA image, spatial standardization and Gauss smoothing were processed using FSL and SPM toolbox. Two independent sample t - tests was used to analyze smoothed white matter map and compare differences in fractional anisotropy between the two groups. Results Compared with healthy controls, bipolar I disorder patients showed elevated FA value in the right cerebellum posterior lobe ( P < 0. 01 ) and decreased FA value in superior temporal gyrus, cerebellum anterior lobe, left insula and left caudate ( P < 0. 01 ) . Conclusion There was impaired white matter integrity in bipolar I disorder patients. The impaired integrity in the limbic sys tem, temporal lobe and cerebellar white matter may berelated to the pathophysiological mechanism of bipolar I disorder. |
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