| ,Effect of adjunctive berberine on blood lipids in patients with schizophrenia:a Meta - analysis[J].SICHUAN MENTAL HEALTH,2019,32(2):143-148 |
| Effect of adjunctive berberine on blood lipids in patients with schizophrenia:a Meta - analysis |
DOI：10.11886/j.issn.1007-3256.2019.02.011 |
| English keywords:Berberine Blood lipid Meta - analysis |
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| Objective To systematically evaluate the effect of berberine on blood lipids levels in patients with schizophrenia,so as to provide references for the intervention program of blood lipid in patients with schizophrenia. Methods Randomized controlled clinical trials ( RCTs ) in English databases ( PubMed, PsycINFO, Embase, Cochrane library) and Chinese databases ( CNKI, Wanfang) were retrieved. The literature screening, data extraction and quality assessment were independently completed by two researchers. RevMan 5. 3 was used for Meta - analysis. Results A total of 3 RCTs ( n = 207) were included, including 103 patients in the berberine group and 104 patients in the control group. Meta - analysis showed that the blood triglyceride level in the berberine group was lower than that in the control group ( WMD = - 0. 54, 95% CI: - 0. 75 ~ - 0. 33) , with statistic difference( P < 0. 01 ) .The cholesterol level of the berberine group was lower than that of the control group ( WMD = - 0. 48, 95% CI: - 0. 67 ~ - 0. 29) ,with statistic difference ( P < 0. 01 ) . The low - density lipoprotein cholesterol level of the berberine group was lower than the control group ( WMD = - 0. 56, 95% CI: - 0. 74 ~ - 0. 38) , with statistic difference ( P < 0. 01 ) . The high - density lipoprotein cholesterol level in the berberine group was higher than that in the control group ( WMD = 0. 06, 95% CI: 0. 02 ~ 0. 10) , with statistic difference ( P < 0. 01 ) . Conclusion The application of berberine combined with antipsychotic drugs can effectively ameliorate the blood lipids levels as well as regulate fat metabolism in patients with schizophrenia. |
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