| ,Micro-environmental changes in brain tissue after mild traumatic brain injury: a multimodal functional magnetic resonance imaging study[J].SICHUAN MENTAL HEALTH,2019,32(3):223-227 |
| Micro-environmental changes in brain tissue after mild traumatic brain injury: a multimodal functional magnetic resonance imaging study |
DOI：10.11886/j.issn.1007-3256.2019.03.006 |
| English keywords:Magnetic resonance spectroscopy Diffusion tensor imaging Mild traumatic brain injury Magnetic sensitive weighted imaging |
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| Objective To investigate the application value of diffusion tensor imaging ( DTI ) combined with magnetic resonance spectroscopy ( MRS) and magnetic sensitive weighted imaging ( SWI) functional magnetic resonance imaging in the assessment of brain tissue metabolism and micro - structural changes after mild traumatic brain injury ( mTBI) , and to provide imaging basis for choosing appropriate treatment options. Methods 21 patients with mTBI and 16 healthy volunteers were enrolled in this study.Patients underwent T1 WI, T2WI, FLAIR, DTI, MRS and SWI sequence scans within 4 ~ 72 hours after injury. The patients with mTBI were evaluated by sequence images and parameter values. The difference among the anterior capsule of the injured side, the hindlimb of the internal capsule, the knee of the corpus callosum, the pressure of the corpus callosum, the cingulate gyrus, the semi - oval center, the white matter of the frontal lobe and the visual radiation were examined. Results Compared with the FA values of the two groups, only FA of the corpus callosum was statistically significant different ( P < 0. 01 ) . The NAA /Cr values in the knees of the mTBI group were significantly lower than those in the control group ( P < 0. 01 ) . The Cho /Cr value in the hind limbs and the corpus callosum were significantly higher in the mTBI group than that in the control group( P < 0. 05 or 0. 01 ) . Conclusion FA value and NAA, Cho, and Cr values may quantitatively determine the diffusion and metabolism of water molecules in brain tissue after mTBI. DTI combined with MRS and SWI could be used as an objective index to quantitatively evaluate the condition and prognosis of patients with mTBI. |
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