| ,Effects of paliperidone on clinical symptoms, cognitive function and serum neurotrophic factor in patients with schizophrenia[J].SICHUAN MENTAL HEALTH,2019,32(3):228-231 |
| Effects of paliperidone on clinical symptoms, cognitive function and serum neurotrophic factor in patients with schizophrenia |
DOI：10.11886/j.issn.1007-3256.2019.03.007 |
| English keywords:Paliperidone Schizophrenia Nerve growth factor Neurotrophin 3 Brain derived neurotrophic factor |
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| Objective To investigate the effects of paliperidone on clinical symptoms, cognitive function and serum neurotrophic factor in patients with schizophrenia, in order to provide a reference for clinical rational drug application. Methods Sixty patients who were hospitalized in Tianjin Anding Hospital and were compliance with the International Classification of Diseases, tenth edition ( ICD - 10) schizophrenia diagnostic criteria were selected as the study group. Meanwhile, 60 healthy volunteers were recruited as the control group. The study group patients were treated with paliperidone for 12 weeks. And the clinical symptoms were evaluated with the Positive and Negative Syndrome Scale( PANSS) . The cognitive function of subjects before and after treatment were evaluated by Stroop Color - Word Test ( SCWT) , Digit - Symbol Coding Test ( DSCT) , Continuous Performance Test ( CPT) and Trail Making Test - A( TMTA) . The serum levels of Brain derived neurotrophic factor ( BDNF) , Nerve Growth Factor ( NGF) and Neurotrophin 3 ( NT - 3) were measured by enzyme - linked immunosorbent assay. Results PANSS total score between before and after treatment of the study group was statistically significant [ ( 78. 12 ± 11 . 84) vs. ( 38. 45 ± 7. 24) , Z = 24. 14, P < 0. 01 ] . In the study group, the cognitive function index ( SCWT?CPT?DCST and TMTA) , BDNF, NGF and NT - 3 levels were higher than before treatment, but still lower than the control group, and the difference were all statistically significant ( P < 0. 01 ) . Conclusion Paliperidone could improve the clinical symptoms and cognitive function in patients with schizophrenia, and its treatment mechanism may be related to up - regulate the levels of serum neurotrophic factor. |
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