| ,Randomized doubled blind controlled study of Jitai tabelets treating protracted syndrome mild heroin addicts[J].SICHUAN MENTAL HEALTH,2019,32(3):232-237 |
| Randomized doubled blind controlled study of Jitai tabelets treating protracted syndrome mild heroin addicts |
DOI：10.11886/j.issn.1007-3256.2019.03.008 |
| English keywords:Mild heroin addicts Jitai tabelets Protracted withdrawal symptoms |
| Fund projects:国家科技支撑计划项目(2008BAI49B02);广东省医学科研基金(A2014835);清远市科技计划项目(2014B010,2014B029) |
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| Objective To investigate the efficacy and safety of Jitai tabelets in the treatment of protracted withdrawal symptoms and to provide references for reducing relapse rate in mild heroin addicts. Methods From July 2011 to February 2012, a total of 81 mild heroin addicts who met the criteria of Diagnostic and Statistical Manual of Mental Disorders, fourth edition ( DSM - IV) were selected from the first compulsory and isolation drug rehabilitation center in Xinxiang, He'nan. The random number table methodwas used to divide the patients into the Jitai tabelets group ( n = 40) and the control group ( n = 41 ) . Both two groups received medicine for 24 weeks. Rating Scale for Protracted Withdrawal Symptoms of Heroin Addicts ( RSPWSHA) was used to measure the efficacy. Hamilton Anxiety Scale ( HAMA) , Hamilton Depression Scale - 17 item ( HAMD - 17 ) and Heroin Craving Questionnaire( HCQ) were used to assess anxiety, depression symptoms and heroin craving symptoms. During the treatment, adverse drug reactions,vital signs and laboratory examination indexes were monitored to evaluate the safety. Results In the two groups, the total scores of RSPWSHA, HAMA, HAMD - 17 and HCQ decreased with the time of treatment ( P < 0. 05 ) , and the reduction rate of RSPWSHA score increased along with treatment ( P < 0. 05 ) . The HCQ score of the two groups after 8 weeks of treatment and the HAMD - 17score of the two groups after 24 weeks of treatment were significantly different from before the treatment ( P < 0. 05 ) . There was no significant difference in scale scores between the two groups at other treatment time points ( P > 0. 05) . Conclusion Jitai tabelets may not be effective in the treatment of protracted withdrawal symptoms for mild heroin addicts. |
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