| ,Clinical efficacy of lorazepam combined with low-frequency repetitive transcranial magnetic stimulation on chronic insomnia disorder[J].SICHUAN MENTAL HEALTH,2019,32(4):337-341 |
| Clinical efficacy of lorazepam combined with low-frequency repetitive transcranial magnetic stimulation on chronic insomnia disorder |
DOI：10.11886/j.issn.1007-3256.2019.04.010 |
| English keywords:Chronic insomnia disorder Low-frequency repetitive transcranial magnetic stimulation Depression Anxiety |
| Fund projects:2017年东莞市社会科技发展一般项目（201750715006126） |
|
| Hits: |
| Download times: |
| English abstract: |
| Objective To investigate the clinical efficacy of lorazepam combined with low-frequency repetitive transcranial magnetic stimulation (rTMS) on chronic insomnia disorder, and to provide clinical references for the treatment of chronic insomnia disorder.Methods A total of 120 patients with chronic insomnia disorder who met the diagnostic criteria for chronic insomnia in the Guidelines for the Diagnosis and Treatment of Insomnia Disorder in China were enrolled, and patients were divided into two groups according to the random number table method, with 60 cases in each group. The study group received the lorazepam combined with low-frequency rTMS, while the control group received the lorazepam combined with pseudo low-frequency rTMS. Polysomnography (PSG) was performed before treatment and 4 weeks after treatment. Before treatment and at the 1st, 2nd and 4th weekend of treatment, all patients were assessed by Pittsburgh Sleep Quality Index (PSQI), Hamilton Depression Scale-17 item (HAMD-17) and Hamilton Anxiety Scale (HAMA).Results ① At the 4th weekend of treatment, the PSQI score of the study group was lower than that of the control group (t=-3.506, P=0.001), the significant effective rate and effective rate of the study group were higher than those of the control group (χ2=4.658, 5.926, P<0.05). The total sleep time and sleep efficiency of the study group were higher than those of the control group (t=2.333~3.784, P<0.05), while the sleep latency, awake time, wake times and REM sleep latency were all lower than those of the control group (t=-2.903~-2.214, P<0.05). ②After treatment for 4 weeks, the HAMA scores of the study group were lower than those of the control group (t=-2.072, P<0.05). At the 1st, 2nd, 4th weekend, HAMD-17 scores of the study group were lower than those of the control group (t=-2.190~-1.701, P<0.05).Conclusion Lorazepam combined with low-frequency rTMS for patients with chronic insomnia disorder may improve their sleep quality, and relieve their negative emotions such as depression and anxiety. |
| View Full Text
View/Add Comment Download reader |
| Close |
|
|
|