| Fan Yanfei,Sun Hongli,Liu Meiling,Xu Aiping,Effect of mirtazapine combined with computerized cognitive behavioral therapy on mild to moderate depression and its impact on quality of life[J].SICHUAN MENTAL HEALTH,2019,32(5):413-417 |
| Effect of mirtazapine combined with computerized cognitive behavioral therapy on mild to moderate depression and its impact on quality of life |
DOI：10.11886/j.issn.1007-3256.2019.05.006 |
| English keywords:Depression Computerized cognitive behavioral therapy Quality of life |
| Fund projects:潍坊市科技发展计划项目（2018YX065） |
| Author Name | Affiliation | Postcode | | Fan Yanfei | The First Affiliated Hospital, Anhui Medical University, Hefei 230022, China | 230022 | | Sun Hongli | Weifang Mental Health Center, Weifang 261061, China | 261061 | | Liu Meiling | The First Affiliated Hospital, Anhui Medical University, Hefei 230022, China | 230022 | | Xu Aiping | Weifang Mental Health Center, Weifang 261061, China | 261061 |
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| Objective To explore the effect of mirtazapine combined with computerized cognitive behavioral therapy (CCBT) on mild to moderate depression and the quality of life of patients, and to provide references for the psychotherapy of mild to moderate depression.A total of 96 patients with mild to moderate depression who met the diagnostic criteria of Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) were selected and divided into study group and control group by random number table method. The control group was given mirtazapine, and the study group was treated with mirtazapine combined with CCBT for 12 weeks. The Hamilton Depression Scale-17 item (HAMD-17) was used to evaluate depressive symptoms and efficacy before and after 2, 4, 6 and 12 weeks of treatment. The World Health Organization Quality of Life Scale (WHOQOL-BREF) was used to evaluate quality of life before and after treatment. At the end of the 12th week, the Morisky Medication Adherence Scale-8 item (MMAS-8) was used to evaluate treatment adherence. Treatment Emergent Symptom Scale (TESS) was used in the treatment to evaluate the side effects of the drug.Results At treatment for 12 weeks, the HAMD-17 score of the study group was lower than that of the control group (P<0.05). The scores of WHOQOL-BREF’s physiological, psychological, social relationship and environmental field, overall health status and quality of life in study group were lower than those of the control group (P<0.01). After treatment, the score of MMAS-8 in the study group was higher than that of the control group (P<0.05). There was no significant difference in adverse drug reactions between the two group (P>0.05).Conclusion The effect of mirtazapine combined with CCBT on mild and moderate depression and quality of life is better than that of mirtazapine alone. |
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