| Wang Jun,Ma Yuanye,Wei Changli,Yin Xuemei,Ma Zhongmei,Effect of mianserin on symptoms of depression and sleep quality[J].SICHUAN MENTAL HEALTH,2019,32(5):418-421 |
| Effect of mianserin on symptoms of depression and sleep quality |
DOI：10.11886/j.issn.1007-3256.2019.05.007 |
| English keywords:Depression disorder Sleep disorders Mianserin Paroxetine |
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| Author Name | Affiliation | Postcode | | Wang Jun | The Third Hospital of Tianshui, Tianshui 741000, China | 741000 | | Ma Yuanye | The Third Hospital of Tianshui, Tianshui 741000, China | 741000 | | Wei Changli | The Third Hospital of Tianshui, Tianshui 741000, China | 741000 | | Yin Xuemei | Wuwei Red Cross Psychiatric Hospital,Wuwei 733000, China | 733000 | | Ma Zhongmei | Wuwei Red Cross Psychiatric Hospital,Wuwei 733000, China | 733000 |
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| English abstract: |
| Objective To investigate the effect of mianserin on symptoms of depression and sleep quality, and to provide references for related clinical drug selection.Methods Based on the International Classification of Diseases, tenth edition (ICD-10), a total of 60 patients with first or recurrent depression in the Third Hospital of Tianshui and Wuwei Red Cross Psychiatric Hospital from May 2017 to February 2018 were selected, and were divided into the mianserin group (n=29) and paroxetine group (n=31) by random number table method. After continuous treatment of 6 weeks, the clinical efficacy and adverse reactions were assessed with Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale-24 item (HAMD-24) and Treatment Emergent Symptom Scale (TESS).Results After treatment, the effective rate of the mianserin group showed no significant difference with that of the paroxetine group (79.3% vs. 80.0%, P=0.948). The scores of the sleep factor in HAMD-24 at the 1st and 2nd weekend of treatment showed significant difference between the two groups [(0.70±0.61) vs. (1.15±0.88), t=-2.17, P=0.035], [(0.37±0.57) vs. (0.81±0.85), t=-2.22, P=0.031]. There was no statistically significant difference in the incidence of adverse reaction between the two groups (79.3% vs. 80.0%, χ2=0.004, P>0.05).Conclusion The efficacy of mianserin and paroxetine in treating depression is similar, but mianserin may be more appropriate for patients with sleep problems. |
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