| Long Yongjun,Zhuo Lihua,Tang Chungeng,Huang Guoping,Zhou Ming,Spontaneous neural activity differences associated with antidepressant response in patients with major depressive disorder: a Meta-analysis[J].SICHUAN MENTAL HEALTH,2020,33(2):150-155 |
| Spontaneous neural activity differences associated with antidepressant response in patients with major depressive disorder: a Meta-analysis |
DOI：10.11886/scjsws20190710001 |
| English keywords:Major depressive disorder Meta-analysis Treatment response Brain functional image |
| Fund projects:绵阳市卫生健康委员会科研项目（项目名称：利用Meta分析研究缓解期和发作期重型抑郁症患者静息态脑功能影像改变） |
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| Objective To explore the spontaneous neural activity differences associated with antidepressant response in patients with major depressive disorder (MDD), and to search for imaging indicators related to the treatment response of MDD.Methods Researches related to the resting-state fMRI of MDD published in Chinese databases (CNKI, Wanfang, VIP) and English databases (PubMed, Embase and Web of Science) were retrieved, and Meta-analysis was performed using AES-SDM.Results A total of 288 patients and 304 healthy controls in 8 literatures were enrolled in this study. Meta-analysis showed that functional activity in the left cerebellum (peak coordinates: X=-22, Y=-78, Z=-18, SDM-Z=1.458), left temporal lobe (peak coordinates: X=-50, Y=-30, Z=-8, SDM-Z=1.539) and right angular gyrus (peak coordinates: X=48, Y=-66, Z=36, SDM-Z=1.536) of MDD patients with effective treatment was increased, while functional activity in the left auxiliary motor area (peak coordinates: X=-10, Y=-2, Z=72, SDM-Z=-1.107) was decreased. In MDD patients with no response to treatment, bilateral superior frontal gyrus and anterior cingulate gyrus (peak coordinates: X=12, Y=42, Z=-4, SDM-Z=1.526) showed increased brain functional activity, while the left inferior frontal gyrus (peak coordinates: X=-48, Y=16, Z=6, SDM-Z=-1.912) showed decreased brain functional activity.Conclusion The change of spontaneous neural activity in cerebellum can be used to predict the treatment response of MDD patients. |
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