| Xu Caixia,Tang Chaohua,Yu Yang,Li Runyi,Deng Danwen,Xie Guojun,Clinical efficacy of high-frequency rTMS combined with duloxetine for adolescents with first-episode generalized anxiety disorder and its effect on cognitive function[J].SICHUAN MENTAL HEALTH,2020,33(4):326-329 |
| Clinical efficacy of high-frequency rTMS combined with duloxetine for adolescents with first-episode generalized anxiety disorder and its effect on cognitive function |
DOI：10.11886/scjsws20200225006 |
| English keywords:High-frequency rTMS Generalized anxiety disorder Cognitive function |
| Fund projects:佛山市医学类科技攻关项目（项目名称：青年期广泛性焦虑障碍的认知缺陷、内分泌变化的关联影响及干预研究，项目编号：2018AB002871）；佛山市十三五医学重点专科和特色专科建设（项目编号：FSTSZK002） |
| Author Name | Affiliation | Postcode | | Xu Caixia | The Third People’s Hospital of Foshan, Foshan 528041, China | 528041 | | Tang Chaohua | The Third People’s Hospital of Foshan, Foshan 528041, China | 528041 | | Yu Yang | The Third People’s Hospital of Foshan, Foshan 528041, China | 528041 | | Li Runyi | The Third People’s Hospital of Foshan, Foshan 528041, China | 528041 | | Deng Danwen | The Third People’s Hospital of Foshan, Foshan 528041, China | 528041 | | Xie Guojun | The Third People’s Hospital of Foshan, Foshan 528041, China | 528041 |
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| Objective To investigate the clinical efficacy and safety of high-frequency repetitive transcranial magnetic stimulation (rTMS) combined with duloxetine for adolescents with first-episode generalized anxiety disorder(GAD), and to analyze its effect on cognitive function.Methods A total of 90 adolescents who met the diagnostic criteria of the International Classification of Diseases, tenth edition (ICD-10) for first-episode GAD were included, and divided into two groups. Study group received high-frequency rTMS (10 Hz) combined with duloxetine, whereas control group received pseudo rTMS combined with duloxetine for 4 weeks. Hamilton Depression Scale - 17 item (HAMD-17) was used to assess the depressive symptoms before the treatment. Hamilton Anxiety Scale (HAMA) was used to evaluate efficacy at the baseline and the 1st, 2nd and 4th weekend of the treatment. MATRICS Consensus Cognitive Battery (MCCB) was used to evaluate cognitive function at the baseline and the 4th weekend of treatment, and TESS was used to evaluate adverse reactions at the 4th weekend of treatment.Results Compared with baseline data, HAMA scores were decreased in both groups after treatment (P<0.01). At the 4th weekend of treatment, the total response rate of study group was higher than that of control group (88.89% vs. 73.81%, χ2=2.100, P=0.040), and the scores of reasoning, problem solving and social cognition of study group were higher than those of control group (P<0.05). After treatment, TESS score showed no significant difference between groups [(2.48±0.86) vs. (2.14±0.78), χ2=0.640, P=0.420].Conclusion High-frequency rTMS combined with duloxetine has a better efficacy on GAD, and it can effectively improve cognitive functions such as reasoning, problem solving and social cognition. |
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