| Duan Changrong,Miao Wei,Gao Zidan,Leng Huan,Zhu Xianglu,Effect of probiotic on depression: a Meta-analysis[J].SICHUAN MENTAL HEALTH,2020,33(3):249-256 |
| Effect of probiotic on depression: a Meta-analysis |
DOI：10.11886/scjsws20200301002 |
| English keywords:Probiotic Depression Meta-analysis |
| Fund projects:贵州省科技厅联合基金项目（项目名称：抗抑郁药物对胃粘膜的保护作用，项目编号：黔科合LH字[2014]7109） |
| Author Name | Affiliation | Postcode | | Duan Changrong | Guizhou Medical University, Guiyang 550004, China | 550004 | | Miao Wei | Guizhou Medical University, Guiyang 550004, China | 550004 | | Gao Zidan | Guizhou Medical University, Guiyang 550004, China | 550004 | | Leng Huan | Guizhou Medical University, Guiyang 550004, China | 550004 | | Zhu Xianglu | Guizhou Medical University, Guiyang 550004, China | 550004 |
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| Objective To provide evidence-based references for probiotics treatment of depression, the efficacy of probiotics on depression is systematically evaluated in this paper.Methods Based on PubMed, Embase, CNKI, Wanfang database, VIP database and other systematic retrievals, the randomized controlled study of probiotics to suppress depression was conducted with two researchers working on literature selection and data extraction. Meta-analysis, sensitivity test and publication bias test were performed using Stata 16.0, and subgroup analysis was conducted based on the assessment tool, depression type and age grouping.Results A total of 17 RCTs (n=1 192) were included. The analysis of random effects models showed after using probiotics, the score changes in the scale of the experimental group was proved to be better than those of the control group, which was statically significant (SMD=-0.50, 95% CI: -0.80~-0.21, Z=3.31, P<0.01). The subgroup analysis by depression type indicates statistically significant differences between the experimental group and the control group in the depression combined diseases group and the healthy group (depression combined diseases group SMD=-0.33, 95% CI: -0.63~0.04, Z=2.21, P=0.03; healthy group SMD=-0.67, 95% CI: -1.09~-0.24, Z=3.07, P<0.01). In the subgroup analysis grouped by age, the difference between the experimental group and the control group of the youth group was statistically significant (SMD=-0.50, 95% CI: -0.81~-0.19, Z=3.18, P<0.01).Conclusion Probiotics can alleviate depression to some extent, but the efficacy is affected by patients’ age and whether they have combined diseases or not. |
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