| Xu Guosheng,Che Peng,Hu Jun,Huang Ke,Li Linguo,Tang Daoxiong,Efficacy and safety of amisulpride and risperidone in the treatment of senile schizophrenia:a Meta-analysis[J].SICHUAN MENTAL HEALTH,2020,33(4):342-348 |
| Efficacy and safety of amisulpride and risperidone in the treatment of senile schizophrenia:a Meta-analysis |
DOI：10.11886/scjsws20200319001 |
| English keywords:Amisulpride Risperidone Senile Schizophrenia Meta-analysis |
| Fund projects: |
| Author Name | Affiliation | Postcode | | Xu Guosheng | Sichuan Mental Health Center·The Third Hospital of Mianyang, Mianyang 621000, China | 621000 | | Che Peng | Sichuan Mental Health Center·The Third Hospital of Mianyang, Mianyang 621000, China | 621000 | | Hu Jun | Sichuan Mental Health Center·The Third Hospital of Mianyang, Mianyang 621000, China | 621000 | | Huang Ke | Sichuan Mental Health Center·The Third Hospital of Mianyang, Mianyang 621000, China | 621000 | | Li Linguo | Sichuan Mental Health Center·The Third Hospital of Mianyang, Mianyang 621000, China | 621000 | | Tang Daoxiong | Sichuan Mental Health Center·The Third Hospital of Mianyang, Mianyang 621000, China | 621000 |
|
| Hits: |
| Download times: |
| English abstract: |
| Objective To systematically evaluate the efficacy and safety of amisulpride and risperidone in the treatment of senile schizophrenia, and to provide reference for the selection of drug.Methods All literature were searched in PubMed, Cochrane Library, Embase, CNKI, Wanfang database and Weipu database . The randomized controlled trials (RCT) on the efficacy and safety of amisulpride and risperidone in the treatment of senile schizophrenia were included. Two reviewers evaluated the quality of the literature and extracted data independently, then used RevMan 5.3 for Meta-analysis.Results A total of 7 RCTs were included. Meta-analysis results showed as below: ① There was no statistically significant difference in the total PANSS scores of 2 weeks, 4 weeks, 6 weeks, and 8 weeks after treatment with amisulpride and risperidone in senile patients with schizophrenia (P>0.05). ② There was no statistically significant difference in the negative symptom scores of 4 and 8 weeks after treatment with amisulpride and risperidone in senile schizophrenia (P>0.05). ③ There was no statistically significant difference in the positive symptom scores of 4 and 8 weeks after treatment with amisulpride and risperidone in senile schizophrenia (P>0.05). ④ No difference was found in the occurrenct of insomnia, tachycardia, tremor, dizziness, headache, akathisia, muscle rigidity and gastrointestinal reactions in the two groups(P>0.05).Conclusion Amisulpride and risperidone have equivalent efficacy and safety in the treatment of senile schizophrenia. |
| View Full Text
View/Add Comment Download reader |
| Close |
|
|
|