| Wang Daojin,Kan Bo,Wang Mei,Zhang Jiahui,Wang Dingxiang,Focus on the complexity of bipolar mixed states in clinical practice[J].SICHUAN MENTAL HEALTH,2020,33(6):481-485 |
| Focus on the complexity of bipolar mixed states in clinical practice |
DOI：10.11886/scjsws20200930001 |
| English keywords:Bipolar disorder Mixed states Mixed episode/features Subsyndromal symptoms DSM-5 ICD-10 Atypical antipsychotics |
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| The purpose of this paper is to review the evolution of the concept，prevalence， clinical correlates， and current evidence for biological treatments of bipolar mixed states， emphasize the illness complexities of bipolar mixed states while highlighting the gaps in clinical treatment and research using International Classification of Diseases，tenth edition （ICD-10） criteria. Narrowly defined ICD-10 mixed episodes ignores subthreshold symptoms of the opposite pole common with patients. Further clinical studies specifically designed to enroll the full range of mixed states are needed to promote appropriate treatment options and improve clinical outcomes. |
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