Zhang Yang,Zhang Leijing,Yang Haibo,Xu Yang,Hou Zhaoxiang,Zhou Yueming,Zhao Yang,Zhao Xiwu,Changes of CD4⁺CD25⁺CD127^- regulatory T cells in peripheral blood of patients with first-episode depression[J].SICHUAN MENTAL HEALTH,2020,33(6):537-541

Changes of CD4⁺CD25⁺CD127^- regulatory T cells in peripheral blood of patients with first-episode depression

DOI：10.11886/scjsws20200616001

English keywords:Depression CD4⁺CD25⁺CD127^-regulatory T cells Immune imbalance Cytokines

Fund projects:黑龙江省卫生计生委科研课题（项目名称：首发抑郁症患者治疗前后外周血中CD4+CD25+Foxp3+调节性T细胞的检测及意义；项目编号：2017-453）

Author Name	Affiliation	Postcode
Zhang Yang	The Third Hospital of Daqing，Daqing 163712， China	163712
Zhang Leijing	The Fourth Affiliated Hospital of Harbin Medical University， Harbin 150001， China	150001
Yang Haibo	The Third Hospital of Daqing，Daqing 163712， China	163712
Xu Yang	The Third Hospital of Daqing，Daqing 163712， China	163712
Hou Zhaoxiang	The Third Hospital of Daqing，Daqing 163712， China	163712
Zhou Yueming	Daqing Saertu District People’s Hospital， Daqing 163000， China	163000
Zhao Yang	The Third Hospital of Daqing，Daqing 163712， China	163712
Zhao Xiwu	The Third Hospital of Daqing，Daqing 163712， China	163712

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English abstract:

Objective To investigate the changes of CD4⁺CD25⁺CD127^-/CD4⁺ ratio in peripheral blood of patients with first-episode depre ssion before and after treatment， and to analyze the correlation between Treg cells and antidepressant treatment efficacy.Methods A total of 20 patients with first episode depression in Inpatient Department of the Third Hospital of Daqing who met the diagnostic criteria of Diagnostic and Statistical Manual of Mental Disorders’fifth edition （DSM-5） for major depressive disorder and scored above 20 points in Hamilton Depression Scale-17 item（HAMD-17） were recruited， meanwhile， another 20 healthy individuals in Physical Examination Center were enrolled as healthy control group. Before and 12 weeks after treatment， HAMD-17 scale was used to assess the depression symptoms of selected patients， and flow cytometry （FCM） was used to detect the CD4⁺CD25⁺CD127^-Treg/CD4⁺T cells ratio in peripheral blood of all selected subjects. Then the comparison analysis was carried out.Results The pre- and post-treatment CD4⁺CD25⁺CD127^-/CD4⁺ levels of depression patients were higher than those of healthy controls （P<0.01）. Among depression patients， there was a decrease in HAMD-17 score and serum CD4⁺CD25⁺CD127^-/CD4⁺ levels after treatment （P<0.05）. Moreover， the reduction rate of CD4⁺CD25⁺CD127^-/CD4⁺ of depression patients with clinical response was positively correlated with the reduction rate of HAMD-17 （r=0.716， P<0.05）.Conclusion Levels of peripheral blood CD4⁺CD25⁺CD127^-/CD4⁺ of depression patients with 12 weeks of SSRI treatment have a significant decrease， and the antidepressant efficacy may have certain correlations with regulatory T cells.

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