| Yang Xiaomin,Bao Tianhao,Ruan Ye,An overview of the risk factors for Alzheimer’s disease[J].SICHUAN MENTAL HEALTH,2020,33(6):560-565 |
| An overview of the risk factors for Alzheimer’s disease |
DOI：10.11886/scjsws20200710001 |
| English keywords:Alzheimer’s disease Risk factors Primary prevention Secondary prevention |
| Fund projects:国家科学自然基金项目（项目名称：miR-124/MACF1 信息轴在机体运动改善TBI所致认知障碍过程中的机制研究,项目编号：81860236）；昆明市卫生科技人才培养暨技术中心建设项目(项目名称：阿尔茨海默病的早期诊断及筛查研究,项目编号：SW（技）-33) |
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| The purpose of this paper is to investigate the possible risk factors， pathogenesis and prevention strategy of Alzheimer’s disease （AD）. The risk factors of AD can be classified into modifiable part and unmodifiable part， of which the unmodifiable part mainly involves in age， gender and genetic risk factors， and the modifiable part mainly involves in diabetes， midlife hypertension， midlife obesity， lack of physical activity， depression， smoking， low education level， sleep disorder etc. In addition， exposure of metal elements in the environment， history of brain injury， history of hypothyroidism and alteration of intestinal flora were also considered as risk factors of AD. The research status of these risk factors and their possible pathogenesis are discussed in this paper. |
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