| Li Xuanzi,She Shenglin,Kuang Qijie,Bi Taiyong,Zong Kunlun,Deng Chanjie,Zheng Yingjun,Study of working memory deficit on the diagnosis of first-episode schizophrenia[J].SICHUAN MENTAL HEALTH,2020,33(4):330-334 |
| Study of working memory deficit on the diagnosis of first-episode schizophrenia |
DOI：10.11886/scjsws20200724001 |
| English keywords:Cognitive load Visual working memory Face perception First-episode schizophrenia |
| Fund projects:国家自然科学基金资助项目（项目名称：在“鸡尾酒会”环境下精神分裂症患者言语识别能力障碍的心理和神经机制，项目编号：81671334）；广州市卫生健康委员会西医类-一般引导项目（项目名称：精神分裂症视觉失匹配负波事件相关电位及视觉任务下加工缺损特征，项目编号：20191A011041）；广州市科学研究计划项目（项目名称：精神分裂症面孔情绪认知障碍的神经机制研究，项目编号：201904010267） |
| Author Name | Affiliation | Postcode | | Li Xuanzi | The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou 510370, China | 510370 | | She Shenglin | The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou 510370, China | 510370 | | Kuang Qijie | The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou 510370, China | 510370 | | Bi Taiyong | School of Management, Zunyi Medical University, Guizhou 563006, China | 563006 | | Zong Kunlun | The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou 510370, China | 510370 | | Deng Chanjie | The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou 510370, China | 510370 | | Zheng Yingjun | The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou 510370, China | 510370 |
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| Objective To explore the working memory deficit of first-episode schizophrenia patients perceived different cognitive loads, and to analyze its relationship with symptomatology and social function, so as to provide reference for early diagnosis of schizophrenia.Methods 32 outpatients with first-episode schizophrenia in the Affiliated Brain Hospital of Guangzhou Medical University from September 2016 to July 2017 who met the diagnostic criteria of Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) were recruited, meanwhile, another 35 healthy individuals were also enrolled as control group. Patients were assessed using Positive and Negative Syndrome Scale (PANSS) and Personal and Social Performance scale (PSP). The visual working memory of all selected subjects was assessed by completing delayed match-to-sample tasks consisted of pairs of faces and houses. Then the correlation analysis was used to elucidate the relationship between the visual working memory and clinical symptoms of patients.Results Schizophrenic patients had impaired working memory for faces and houses (F>16, P<0.01). The difference in accuracy of house working memory between patients and healthy controls was gradually narrowed with the increase of memory loads (F>9, P<0.01). The performance of working memory in patient group was not correlated with course of disease, severity of symptoms, or dose of antipsychotic drugs (P>0.05).Conclusion First-episode schizophrenia patients have visual working memory deficit, in which face working memory deficits are not affected by cognitive load, so it may be one of the basis for early diagnosis of schizophrenia. |
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