Fu Bingbing,Wang Xueqi,Zhang Ling,Wang Gang,Analysis on the use of antidepressants in inpatients with depression from 2015 to 2019[J].SICHUAN MENTAL HEALTH,2021,34(2):126-130

Analysis on the use of antidepressants in inpatients with depression from 2015 to 2019

DOI：10.11886/scjsws20210302004

English keywords:Depressive disorder Medication Trend

Fund projects:北京市医院管理中心临床医学发展专项“扬帆”计划临床技术创新项目（项目名称：基于肝药酶基因多态性和TDM的抑郁症精准量化治疗模式研究，项目编号：XMLX202128）

Author Name	Affiliation	Postcode
Fu Bingbing	The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders， Beijing Anding Hospital， Capital Medical University， Beijing 100088， China	100088
Wang Xueqi	The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders， Beijing Anding Hospital， Capital Medical University， Beijing 100088， China	100088
Zhang Ling	The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders， Beijing Anding Hospital， Capital Medical University， Beijing 100088， China The Advanced Innovation Center for Human Brain Protection， Capital Medical University， Beijing 100069， China	100069
Wang Gang	The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders， Beijing Anding Hospital， Capital Medical University， Beijing 100088， China The Advanced Innovation Center for Human Brain Protection， Capital Medical University， Beijing 100069， China	100069

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English abstract:

Objective To investigate the use of antidepressants in hospitalized patients with depression disorder from 2015 to 2019， and to analyze the changes of these antidepressants and medication regimens， so as to provide references for clinical drug use.Methods Using the Beijing-Tianjin-Hebei big data platform， the data of patients with depression in Beijing Anding Hospital， Capital Medical University from 2015 to 2019 were retrospectively analyzed. The changes of different types of drugs and medication regimens were described.Results From 2015 to 2019， a total of 6 043 cases of eligible patients were enrolled in analysis. Among selective serotonin reuptake inhibitors （SSRIs）， the prescription proportion of sertraline， citalopram and fluoxetine showed a trend of decline （P<0.05 or 0.01）， while the prescription proportion of escitalopram showed a trend of fluctuations （P=0.031）. In serotonin noradrenaline reuptake inhibitors （SNRIs）， the prescription proportion of duloxetine and milnacipran were rising （P<0.01）. The newer antidepressants agomelatine （P=0.001） and voltioxetine （P<0.01） also showed an upward trend. In terms of medication regimen， the proportion of single antidepressants and combined use of two antidepressants showed a downward trend （P<0.01）， while the proportion of antidepressants combined with mood stabilizers， antidepressants combined with mood stabilizers or antipsychotics showed an upward trend （P<0.05 or 0.01）.Conclusion In the 5 years， the proportion of SSRIs decreased， and the proportion of SNRIs and newer antidepressants increased in hospitalized patients with depression. The proportion of antidepressants combined with mood stabilizers and antipsychotics in treatment regimens showed an increasing trend.

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