Chen Yingmei,Chen Minmin,Cai Yinglian,Zhou Yanling,Wu Qiuxia,Zhong Siqian,Zhang Bin,Cao Liping,Correlation between anhedonia level and cognitive function in patients with first-episode psychosis[J].SICHUAN MENTAL HEALTH,2021,34(3):226-230
Correlation between anhedonia level and cognitive function in patients with first-episode psychosis
Fund projects:国家重点研发计划重大慢性非传染性疾病防控研究基金资助项目（项目名称：首发精神分裂症的脑影像、电生理和眼动标记，项目编号：2016YFC1306804）；国家自然科学基金资助项目（项目名称：膜脂调控蛋白Serinc2罕见突变在双相情感障碍加息发病中的作用和机制，项目编号：81771466）
Objective To explore the anhedonia level and its relationship with cognitive function in patients with first-episode psychosis， and to analyze the influencing factors of cognitive function.Methods A total of 143 first-episode psychiatric patients who met the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders， fifth edition （DSM-5） in the Affiliated Brain Hospital of Guangzhou Medical University from December 2016 to March 2019 were selected. Positive and Negative Syndrome Scale （PANSS） was used to evaluate the patient’s psychiatric symptoms， in which N2 （emotional withdrawal） and N4 （passive/apathetic social withdrawal） were used to assess the anhedonia level， and patients whose （N2+N4） scores beyond 4 were classified into anhedonia group， and those with （N2+N4） scores less than or equal to 4 were classified into non-anhedonia group. Hamilton Depression Scale-24 item （HAMD-24） was used to measure the depressive symptoms， and the MATRICS Consensus Cognitive Battery （MCCB） was used to detect cognitive function. Then the clinical symptoms and cognitive function of two groups were compared， and the influencing factors of cognitive function were screened by multiple linear regression analysis.Results The negative symptom score， general pathological symptom score and total score of PANSS in anhedonia group were significantly higher than those of non-anhedonia group， with statistical difference （P<0.05）. The score of working memory in adolescent subgroup， the scores of information processing speed， attention/alertness and vocabulary learning in adult subgroup of anhedonia group were lower than those of non-anhedonia group， with statistical difference （P<0.05）. Multiple linear regression analysis showed that the anhedonia score and the duration of untreated psychosis were the influencing factors of working memory in adolescent subgroup （P<0.05）.Conclusion Patients with high levels of anhedonia suffer more severe mental symptoms and cognitive impairment， moreover， anhedonia is one of the influencing factors of working memory in adolescents.