| Ye Gang,Li Zhe,Pan Wen,Gao Shigeng,Shen Yingying,Liu Ying,Yin Ming,Liu Guorui,Zhao Yu,Shen Jianhong,Du Xiangdong,Characteristics of polysomnography in depression patients complicating moderate-to-severe obstructive sleep apnea hypopnea syndrome[J].SICHUAN MENTAL HEALTH,2021,34(5):424-428 |
| Characteristics of polysomnography in depression patients complicating moderate-to-severe obstructive sleep apnea hypopnea syndrome |
DOI：10.11886/scjsws20210407003 |
| English keywords:Depression Obstructive sleep apnea hypopnea syndrome Polysomnography |
| Fund projects:江苏省卫生计生委面上项目（项目名称：经颅直流电刺激联合正念治疗对抑郁障碍急性期后认知功能的疗效研究，项目编号：H2017069）；苏州市精神疾病临床医学中心青年科教项目（项目名称：伴非典型特征的抑郁障碍患者过度睡眠特点及其与唾液皮质醇水平的关系，项目编号：gjyy201705）；苏州市姑苏卫生人才培养项目（项目名称：经颅直流电刺激对抑郁症患者认知功能、多导睡眠监测及血清BDNF水平影响的临床随访研究，项目编号：GSWS2019070）；苏州市2017年度产业技术创新专项（民生科技-医疗卫生应用基础研究【第二批】）项目（项目名称：C-反应蛋白（CRP）对草酸艾司西酞普兰和文拉法辛疗效的预测研究，项目编号：SYSD2017137）；苏州市姑苏卫生人才计划（项目名称：抑郁症自杀行为的风险决策认知内表型缺陷及其免疫机制研究，项目编号：GSWS2020097） |
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| Objective To investigate the characteristics of polysomnography （PSG） in depression patients complicating moderate-to-severe obstructive sleep apnea hypopnea syndrome （OSAHS）.Methods A retrospective analysis was conducted on the outpatients， inpatients and physical examination population who completed overnight PSG monitoring in the sleep medicine center of Suzhou Guangji Hospital from December 2017 to October 2019. Four groups of subjects were finally enrolled， including depression patients with moderate-to-severe OSAHS （n=31）， depression patients without OSAHS （n=79）， moderate-to-severe OSAHS patients （n=96） and normal control group （n=32）. The sleep process related indicators （total sleep time， sleep latency， number of awakenings）， sleep structure related indicators （N1， N2， N3， percentage of REM sleep， REM latency， REM sleep duration）， sleep-related respiratory variables （oxygen reduction index） and other polysomnographic parameters of the four groups were compared.Results In terms of sleep process， the total sleep time， sleep latency and number of awakenings yielded significant differences among the four groups （F=2.874， 3.959， 12.291， P<0.05 or 0.01）. In terms of sleep structure， the percentage of total sleep time in N2 and N3 stages demonstrated significant differences among the four groups （F=13.885， 48.013， P<0.01）. The REM latency， REM sleep duration and percentage of REM sleep manifested significant differences among the four groups （F=41.492， 11.827， 10.552， P<0.01）. In terms of sleep-related respiratory variables， the oxygen reduction index exhibited significant differences among the four groups （F=170.585， P<0.05）.Conclusion Depression patients complicating moderate-to-severe OSAHS suffer from severe sleep process and structural disturbances， accompanied by quite frequent and severe sleep-related respiratory events. |
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