| Zhang Wenyan,Li Longfei,Song Xiaohui,Li Wu,Effect of antipsychotics on serum uric acid in patients with schizophrenia： a Meta-analysis[J].SICHUAN MENTAL HEALTH,2021,34(6):522-528 |
| Effect of antipsychotics on serum uric acid in patients with schizophrenia： a Meta-analysis |
DOI：10.11886/scjsws20210520001 |
| English keywords:Oxidative stress Schizophrenia Serum uric acid Antipsychotics Meta-analysis |
| Fund projects: |
|
| Hits: |
| Download times: |
| English abstract: |
| Objective To investigate the impact of antipsychotics on serum uric acid level in patients with schizophrenia， and to clarify the antioxidant properties of antipsychotics， so as to provide evidence-based guidelines for the treatment of schizophrenia.Methods Keywords combined with free-text search strategies were used to retrieve English and Chinese databases including PubMed， Embase， Web of Science， Cochrane Library， CNKI， Wanfang Database， VIP database and Chinese Biomedical Literature Database. Randomized controlled trials related to the effects of antipsychotics on serum uric acid level in patients with schizophrenia were included. Meta-analysis was performed using RevMan 5.3.Results A total of 9 kinds of antipsychotics and 1 434 schizophrenia patients in 15 Chinese and English literatures were included. Meta-analysis showed that olanzapine （MD=14.01， 95% CI： 2.39~21.62， P<0.05） and chlorpromazine （MD=51.36， 95% CI： 42.15~60.57， P<0.05） increased the serum uric acid level in schizophrenia patients， while risperidone， aripiprazole， clozapine， haloperidol， quetiapine and ziprasidone had no significant effect on serum uric acid （P>0.05）.Conclusion The effect of different kinds of antipsychotics on serum uric acid level in schizophrenia patients varies， among which olanzapine and chlorpromazine can elevate serum uric acid level in patients with schizophrenia， whereas no other antipsychotics have been found to have any effect on serum uric acid level. |
| View Full Text
View/Add Comment Download reader |
| Close |