| Qi Meng,Meng Fanlei,Song Tianhe,Wang Tingting,Liu Jinmeng,Zhou Shuangjiang,Chen Jingxu,Relationship between objective sleep quality and cognitive function in remission depression patients with insomnia[J].SICHUAN MENTAL HEALTH,2022,35(2):126-131 |
| Relationship between objective sleep quality and cognitive function in remission depression patients with insomnia |
DOI：10.11886/scjsws20211121002 |
| English keywords:Depression Insomnia Sleep quality Cognitive function Remission |
| Fund projects:北京市医院管理中心临床医学发展专项经费（项目名称：网络化失眠认知行为疗法干预缓解期抑郁症失眠的应用研究，项目编号：XMLX202150） |
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| Objective To discuss the relationship between objective sleep quality and cognitive function in remission depression patients with insomnia.Methods A total of 47 patients with depression in remission in Beijing Huilongguan Hospital were enrolled. Insomnia Severity Index （ISI） and the sleep efficiency calculated by the first four items of Pittsburgh Sleep Quality Index （PSQI） were defined as insomnia. Among the selected patients， 22 subjects were classified into insomnia group， and 25 subjects in non-insomnia group. The objective sleep status of all subjects was evaluated by polysomnography （PSG）， and the cognitive function was evaluated with the Repeatable Battery for Assessment of Neuropsychological Status （RBANS）. A regression model was established to explore the relationship between objective sleep quality and cognitive function in remission depression patients with insomnia.Results There was statistically significant difference in immediate memory factor scores of RBANS between depression patients in remission with and without insomnia （t=-2.102， P<0.05）. The sleep efficiency （Z=-2.113， P<0.05）， the proportion of N3 sleep stage （Z=-3.175， P<0.01） and the duration of N3 sleep stage （Z=-3.196， P<0.01） in insomnia group were all lower than those in non-insomnia group， and the nocturnal awakening （Z=-2.058， P<0.01）， the proportion of N1 sleep stage （Z=-2.399， P<0.05） and the duration of N1 sleep stage （Z=-2.463， P<0.05） were higher than those of the insomnia group. Within insomnia group， the increased proportion of REM sleep was correlated with the improvement of attention function （β=0.953， 95% CI： 0.123~2.038， P<0.05）， and the increase of nocturnal awakening was correlated with the decline of delayed memory （β=-0.173， 95% CI： -0.325~-0.024， P<0.05）.Conclusion Objective sleep is associated with cognitive impairment in remission depression patients with insomnia， the proportion of REM sleep has a positive impact on attention function， and frequent nocturnal awakening at night has a negative impact on delayed memory. |
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