| Zhong Jun,Liu Yang,Xu Jianfeng,Zhang Hai,Liao Shuai,Wen Qianhui,Wang Xue,Application of event-related potential P300 in the evaluation of cognitive dysfunction in patients with traumatic brain injury[J].SICHUAN MENTAL HEALTH,2022,35(3):241-244 |
| Application of event-related potential P300 in the evaluation of cognitive dysfunction in patients with traumatic brain injury |
DOI：10.11886/scjsws20220401001 |
| English keywords:Traumatic brain injury Event-related potential P300 Cognitive dysfunction |
| Fund projects:四川应用心理学研究中心项目（项目名称：蛛网膜下腔出血合并阻塞性睡眠呼吸暂停综合征患者认知功能障碍研究，项目编号：CSXL-212B03） |
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| Objective To explore the application value of event-related potential P300 in the evaluation of cognitive dysfunction in patients with traumatic brain injury.Methods From January to September 2021， a total of 36 patients with traumatic brain injury who were conservatively treated in the Neurosurgery Department of the Third Hospital of Mianyang and met the diagnostic criteria were selected as the experimental group. And 36 participants were recruited from the family members and carers of other patients in the hospital as the control group. Oddball paradigm was used to measure the event-related potential P300. Montreal Cognitive Assessment （MoCA） and Mini-Mental State Examination （MMSE） were used to assess the cognitive function of the subjects. The latency and amplitude of P300， MoCA and MMSE scores were compared between two groups. The detection rates of P300 latency， MoCA and MMSE on cognitive dysfunction in patients with traumatic brain injury were compared.Results MoCA and MMSE scores in experimental group were lower than those in control group ［（18.08±4.29） vs. （27.36±1.20）， （22.53±3.54） vs. （28.11±1.09）， t=-12.510， -9.041， P<0.05］. The latency of P300 in experimental group was higher than that in control group ［（406.08±26.95）ms vs. （367.08±22.50）ms， t=6.665， P<0.05］， and the amplitude was lower than that in control group ［（7.76±0.90）μV vs.（9.87±0.99）μV， t=-9.459， P<0.05］. In experimental group， the positive detective rate of P300 latency and MoCA on cognitive dysfunction were higher than that in MMSE （χ2=5.675， 7.604， P<0.05）.Conclusion Event-related potential P300 can be used as an objective clinical indicator for evaluating cognitive dysfunction in patients with traumatic brain injury. |
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