Zhang Yurong,Fang Kun,Zhang Renfei,Wang Fang,Liu Yang,Yang Ping,Wu Yan,Li Lei,Zhao Yuanyu,Cai Zhilong,Yang Jia,Yuan Dan,Analysis of urine Alzheimer-associated neuronal thread protein level and related factors of middle-aged and elderly people in Mianyang[J].SICHUAN MENTAL HEALTH,2023,36(1):53-58

Analysis of urine Alzheimer-associated neuronal thread protein level and related factors of middle-aged and elderly people in Mianyang

DOI：10.11886/scjsws20220504001

English keywords:AD7c-NTP Alzheimer's disease Urine Uric acid

Fund projects:四川省卫生和计划生育委员会科研课题（项目名称：尿阿尔茨海默相关神经丝蛋白（AD7C-NTP）和血清胰岛素联合检测在阿尔茨海默病临床诊断中的应用价值，项目编号：16PJ402）；绵阳市卫健委科研课题（项目名称：绵阳地区健康成年人群尿液AD7C-NTP 参考区间的建立，项目编号：202018）

Author Name	Affiliation	Postcode
Zhang Yurong	Sichuan Science City Hospital， Mianyang 621900， China	621900
Fang Kun	Sichuan Science City Hospital， Mianyang 621900， China	621900
Zhang Renfei^*	The Third Hospital of Mianyang·Sichuan Mental Health Center， Mianyang 621000， China	621000
Wang Fang	Sichuan Science City Hospital， Mianyang 621900， China	621900
Liu Yang	Sichuan Science City Hospital， Mianyang 621900， China	621900
Yang Ping	Sichuan Science City Hospital， Mianyang 621900， China	621900
Wu Yan	Sichuan Science City Hospital， Mianyang 621900， China	621900
Li Lei	Sichuan Science City Hospital， Mianyang 621900， China	621900
Zhao Yuanyu	Sichuan Science City Hospital， Mianyang 621900， China	621900
Cai Zhilong	Sichuan Science City Hospital， Mianyang 621900， China	621900
Yang Jia	Sichuan Science City Hospital， Mianyang 621900， China	621900
Yuan Dan	Sichuan Science City Hospital， Mianyang 621900， China	621900

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English abstract:

Objective To investigate the Alzheimer-associated neurofilament protein （AD7c-NTP） in urine of middle-aged and elderly people and its correlation between common metabolites.Methods A total of 1 150 middle-aged and elderly people who did their physical exmanination in the health examination center of the Sichuan Science City Hospital and the Third Hopital of Mianyang were recruited from March 2017 to March 2020. The level of urine AD7c-NTP were measured by enzyme-linked immunosorbent assay （ELISA）， and common metabolites in blood were measured by biochemical analyzer. Based on urine AD7c-NTP level ≤1.5 ng/mL， the objects was divided into normal group （n=956） and elevated group （n=194）. Thier demographic data and blood biochemical indicators were collected.Results The urine AD7c-NTP level in middle-aged and elderly people was 0.60（0.30~1.20） ng/mL. The urine AD7c-NTP level was higher in women than that in men ［1.04（0.40~1.30） ng/mL vs. 0.84（0.30~1.00） ng/mL， Z=4.202， P?0.01］. And the urine AD7c-NTP level was lower in the normal group than that in the elevated group ［0.50（0.30~0.90） ng/mL vs. 2.10（1.70~2.10） ng/mL， Z=22.035， P?0.01］. The results of the univariate comparison showed that， the differences between the two groups in age （Z=6.545）， fasting glucose （Z=3.506）， blood uric acid （Z=2.574）， urea nitrogen （Z=2.891）， creatinine （Z=2.243）， total bilirubin （Z=3.936）， glutathione （Z=0.969）， total cholesterol （t=3.956） and low density lipoprotein （Z=-5.678） were were statistically significant （P?0.05 or 0.01）. Spearman correlation analysis showed that， the urine AD7c-NTP level was positively correlated with age and the levels of urea nitrogen， glucose， total cholesterol and low density lipoprotein （r=0.177， 0.178， 0.171， 0.109， 0.149， P?0.01）， and negatively correlated with the level of total bilirubin （r=-0.172， P?0.01）.Conclusion the urine AD7c-NTP level in middle-aged and elderly females was signifitcantly higher than in middle-aged and elderly males.The urine AD7c-NTP level of middle-aged and elderly people was positively correlated with age， urea nitrogen， glucose， total cholesterol and low density lipoprotein， and negatively correlated with total bilirubin.

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