| Hao Keke,Wang Huiling,Wang Gaohua,Advances in the study of the roles of mitochondrial dysfunction and neuroinflammation in the pathogenesis of schizophrenia[J].SICHUAN MENTAL HEALTH,2023,36(1):74-79 |
| Advances in the study of the roles of mitochondrial dysfunction and neuroinflammation in the pathogenesis of schizophrenia |
DOI：10.11886/scjsws20220721001 |
| English keywords:Schizophrenia Immuno-inflammation Mitochondria Microglia |
| Fund projects:武汉大学医学腾飞计划（神经科学疾病与功能协同创新平台）（项目编号：TFLC2018001，项目名称：基于多模态神经影像遗传学的精神分裂症发病机制及其治疗反应研究） |
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| This paper aims to present a review of the research progress on the roles of mitochondrial dysfunction and microglia-mediated inflammation in the pathophysiology of schizophrenia. Schizophrenia is a serious psychiatric disorder in which the immuno-inflammatory pathway is considered to be one of the main pathogenic mechanisms of disease， and manifested by microglia activation and elevated levels of inflammatory cytokines in the brain. However， the biological mechanism underlying immune disorder in schizophrenia has not been fully elucidated. In recent years， accumulating evidence has indicated that mitochondrial dysfunction may play a key role in the pathogenesis of schizophrenia. Therefore， this article reviews the research progress on the roles of mitochondrial days function and microglia-mediated inflammation in the pathophysiology of schizophrenia， so as to inform the study of the pathogenesis of schizophrenia. |
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