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| Correlation between functional connectivity of the precuneus and early efficacy to antidepressant treatment in major depressive disorder |
DOI： |
| English keywords:major depressive disorder antidepressant treatment early improvement precuneus functional connectivity |
| Fund projects:国家重点研发项目（2016YFC1307200)，四川省科技厅重点研发项目（2022YFS0345），四川大学华西医院135培育项目（ZYJC21083）和四川大学华西医院学科卓越发展1·3·5工程临床研究孵化项目（2022HXFH029） |
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| Background The activity in precuneus within default mode network has been reported to be associated with antidepressant response， whereas the relationship between the functional network of precuneus and early response to antidepressant medications remains unclear. Objective To investigate the relationship between precuneus functional connectivity （FC） and early response to antidepressant therapy in patients with major depressive disorder， so as to find a neurobiomarker to predict the early response to antidepressants. Methods A consecutive sample of 47 patients with major depressive disorder who attended the Mental Health Center of West China Hospital of Sichuan University from July 2017 to February 2019 and fulfilled the diagnostic criteria of Diagnostic and Statistical Manual of Mental Disorders， fifth edition （DSM-5） were recruited. Baseline resting-state functional magnetic resonance imaging scan findings and clinical assessments were recorded in participants. All patients were subjected to two weeks of antidepressant treatment. Improvement was defined as 20% or greater reduction in baseline 16-Item Quick Inventory of Depressive Symptomatology– Self-Report （QIDS-SR16） by treatment exit， and patients were then classified into early improved group（ n=27） and non-improved group（ n=20）. FC values of precuneus and whole brain were calculated using bilateral precuneus as seed region， and baseline precuneus FC values were compared between two groups. Pearson correlation analysis was utilized to
explore the correlation between FC values in brain regions with statistically significant differences and QIDS-SR16 total scores and reduction rates. Results FC values between the left precuneus and left precentral gyrus and between the right precuneus and right fusiform gyrus in early improved group were both higher than those in non-improved group （GRF correction， P<0. 01）. The FC between the left precuneus and the left precentral gyrus， the right precuneus and the right fusiform gyrus were positively correlated with QIDS-SR16 reduction rate （r=0. 475， 0. 297， P<0. 05）. Conclusion Weakened FC between the left precuneus and left precentral gyrus and between the right precuneus and right fusiform gyrus are related to poor early response to antidepressant treatment， so FC of precuneus may be a potential predictor of early response to antidepressants. ［Funded by the National Key Research & Development Program of China （number， 2016YFC1307204）； Key Development Project of the Sichuan Provincial Science and Technology Plan（ number， 2018SZ0131） |
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