Xiao Lin,Zhang Xiaomei,Wu Kai,Wang Lu,Research progress in the effectiveness and mechanism of hyperbaric oxygen therapy for depression[J].SICHUAN MENTAL HEALTH,2024,37(1):91-96
Research progress in the effectiveness and mechanism of hyperbaric oxygen therapy for depression
DOI:10.11886/scjsws20230208003
English keywords:Hyperbaric oxygen  Depression  Neuroinflammation  Synaptic plasticity
Fund projects:
Author NameAffiliationPostcode
Xiao Lin The Fourth People's Hospital of Chengdu Chengdu 610036 China 610036
Zhang Xiaomei University of Electronic Science and Technology of China Chengdu 611731 China 611731
Wu Kai Wenjiang District People's Hospital of Chengdu Chengdu 611130 China 611130
Wang Lu The Fourth People's Hospital of Chengdu Chengdu 610036 China 610036
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English abstract:
      Hyperbaric oxygen therapy characterized by fewer side effects and simple operation has been explored as a potential therapy for depression. This article provides a review of researches relevant to current clinical application and mechanism of hyperbaric oxygen therapy for depression, aiming to provide valuable references for the formulation of new strategies for the treatment of depression. Hyperbaric oxygen therapy has been demonstrated to be useful as an adjunctive therapy for depression, which can effectively alleviate depression by regulating the homeostasis of hypothalamus-pituitary-adrenal axis, inhibiting inflammation and enhancing synaptic plasticity. And hyperbaric oxygen therapy as adjuvant to antidepressants for depression can contribute to increasing the treatment effectiveness to some extent.
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