| Xiao Hongqi,Yuan Minlan,Zhu Hongru,Cao Yuan,Qiu Changjian,Correlation between functional connectivity of the precuneus and early efficacy to antidepressant treatment in patients of major depressive disorder[J].SICHUAN MENTAL HEALTH,2024,37(3):205-211 |
| Correlation between functional connectivity of the precuneus and early efficacy to antidepressant treatment in patients of major depressive disorder |
DOI：10.11886/scjsws20231219001 |
| English keywords:Major depressive disorder Antidepressant treatment Early efficacy Precuneus Functional connectivity |
| Fund projects:国家重点研发项目（项目名称：基于量化评价技术的抑郁障碍全病程干预策略研究，项目编号：2016YFC1307204）；四川省科技计划项目重点研发项目（项目名称：重型抑郁障碍、广泛性焦虑障碍脑微观结构及静息态功能磁共振研究，项目编号：2018SZ0131） |
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| Background The activity in precuneus within default mode network has been reported to be associated with antidepressant response， whereas the relationship between the functional network of precuneus and early response to antidepressant medications remains unclear. Objective To investigate the relationship between precuneus functional connectivity （FC） and early efficacy of antidepressant treatment in patients with major depressive disorder， so as to find a neurobiomarker to predict the early efficacy of antidepressants. Methods A consecutive sample of 47 patients with major depressive disorder who attended the Mental Health Center， West China Hospital of Sichuan University from July 2017 to February 2019 and fulfilled the diagnostic criteria of Diagnostic and Statistical Manual of Mental Disorders， fifth edition （DSM-5） were recruited. Baseline resting-state functional magnetic resonance imaging scan findings and clinical assessments were recorded in participants. All patients treated with antidepressants for two weeks. Improvement was defined as 20% or greater reduction in baseline 16-item Quick Inventory of Depressive Symptoms Self-Report Scale （QIDS-SR16） by treatment exit， and patients were then classified into early improved group （ n=27） and non-improved group （ n=20）. FC values of precuneus and whole brain were calculated using bilateral precuneus as seed region， and baseline precuneus FC values were compared between two groups. Pearson correlation analysis was utilized to explore the correlation between FC values in brain regions with statistically significant differences and QIDS-SR16 total scores and reduction rates. Results FC values between the left precuneus and left precentral gyrus and between the right precuneus and right fusiform gyrus in early improved group were both higher than those in non-improved group （GRF correction， P<0.01）. The FC valves between the left precuneus and the left precentral gyrus and between the right precuneus and the right fusiform gyrus were positively correlated with QIDS-SR16 reduction rate （ r=0.475， 0.297， P<0.05）. Conclusion Weakened FC between the left precuneus and left precentral gyrus and between the right precuneus and right fusiform gyrus are related to poor early efficacy to antidepressant treatment， and FC of precuneus may be a potential predictor of early response to antidepressants. ［Funded by the National Key Research & Development Program of China （number， 2016YFC1307204）； Key Development Project of the Sichuan Provincial Science and Technology Plan （number， 2018SZ0131）］ |
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