Yang Shuting,Fan Ajiao,Duloxetine hydrochloride induced syndrome of inappropriate antidiuretic hormone secretion in depression treatment： a case report[J].SICHUAN MENTAL HEALTH,2024,37(4):376-378

Duloxetine hydrochloride induced syndrome of inappropriate antidiuretic hormone secretion in depression treatment： a case report

DOI：10.11886/scjsws20240229002

English keywords:Duloxetine hydrochloride Depression Syndrome of inappropriate antidiuretic hormone secretion

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Author Name	Affiliation	Postcode
Yang Shuting	The First School of Clinical Medical of Lanzhou University， Lanzhou 730000， China	730000
Fan Ajiao^*	The Second Hospital of Lanzhou University， Lanzhou 730030， China	730030

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English abstract:

Duloxetine hydrochloride，a serotonin-norepinephrine reuptake inhibitor （SNRIs）， is a commonly used antidepressants. Its mechanism of action involves increasing synaptic monoamine neurotransmitters concentration， leading to antidepressant effects. While gastrointestinal reactions and elevated blood pressure are common side effects， duloxetine can rarely induce syndrome of inappropriate antidiuretic hormone secretion （SIADH）. This case report presents a patient with depression who developed SIADH following duloxetine hydrochloride initiation， with the main clinical manifestation being restless thirst and excessive drinking. This case is presented to raise awareness among clinicians of this rare yet potentially serious adverse effect of duloxetine treatment.

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