| Background The professional self-concept of nurses is a crucial indicator for their personal growth, development, and career planning. Previous studies have shown that stress sources during the internship period may lead to a decrease in the level of professional self-concept among nursing students. However, there are differences in social roles between nursing students and clinical nurses. Influencing factors of professional self-concept in nurses and its relationship with work stressors requires further exploration. Objective To explore the relationship between work stressors and professional self-concept among nurses, so as to provide references for improving the level of professional self-concept of clinical nurses. Methods From December 2022 to February 2023, a stratified random sampling method was employed to select 238 in-service nurses from Mianyang Hospital of Traditional Chinese Medicine as the study subjects. Chinese Nurse’ Stressor Scale (CNSS) and Chinese version of Professional Self-concept of Nurses Instrument (PSCNI) were used for assessment. Pearson correlation analysis was conducted to examine the correlation between CNSS scores and Chinese version of PSCNI scores. Multiple linear regression analysis was utilized to explore the factors influencing the professional self-concept of nurses. Results A statistically significant difference was observed in the total score of the Chinese version of PSCNI among nurses with different marital statuses (F=8.947, 5.183, P<0.05). The total PSCNI scores for nurses with experience in emergency medical assistance were significantly higher than those without such experience (t=2.208, P<0.05). And nurses who had abnormal results in their health check-ups within the past year had lower total PSCNI scores compared to those with normal check-up results (t=-2.584, P<0.05). Correlation analysis results showed that the total score and subscale scores of CNSS were negatively correlated with the total score of Chinese version of PSCNI (r=-0.169, -0.198, -0.193, -0.275, -0.229, -0.237, -0.222, P<0.01). The results of multiple linear regression analysis indicated that stressors related to nurses' expectations, marital status and emergency medical assistance experience might be influencing factors of their professional self-concept（β=-0.350、0.345、0.183，P＜0.01）. Conclusion Nurses' job stressors are negatively correlated with their professional self-concept. High levels of stressors related to nurses' expectations may lead to a decrease in nurses’ professional self-concept levels. Married nurses and those with frontline anti-epidemic work experience may have higher levels of professional self-concept. |