Chen Yadi,Ding Yu,Li Qianqian,Liu Xiaolei,Wang Weiwei,Arrhythmia induced by clozapine in patients with schizophrenia: a Meta-analysis[J].SICHUAN MENTAL HEALTH,2024,37(5):475-481
Arrhythmia induced by clozapine in patients with schizophrenia: a Meta-analysis
DOI:10.11886/scjsws20231211002
English keywords:Clozapine  Schizophrenia  Arrhythmias  Meta-analysis
Fund projects:国家自然科学基金(项目名称:基于树鼩TRS模型研究乳酸代谢异常在CIM过程中的机制,项目编号:NO.82360275);云南省科技厅科技计划项目(项目名称:miRNAs交叉串话介导JAK2/STAT3通路参与SCU对抗I/R心肌细胞调亡机制研究,项目编号:202301AY070001-020);云南省教育厅科学研究基金项目(项目名称:NLRP3在灯盏花素抑制I/R所致心肌细胞焦亡过程中的机制研究,项目编号:2023Y0640);昆明医科大学研究生创新基金(项目名称:氯氮平对TRS患者心脏损伤研究,项目编号:2023S302)
Author NameAffiliationPostcode
Chen Yadi The Second Affiliated Hospital of Kunming Medical University Kunming 650033 China 650033
Ding Yu The Second Affiliated Hospital of Kunming Medical University Kunming 650033 China 650033
Li Qianqian The Second Affiliated Hospital of Kunming Medical University Kunming 650033 China 650033
Liu Xiaolei The First Affiliated Hospital of Kunming Medical University Kunming 650032 China 650032
Wang Weiwei* The Second Affiliated Hospital of Kunming Medical University Kunming 650033 China 650033
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English abstract:
      Background Clozapine belongs to atypical antipsychotic drugs that has shown significant efficacy in treating schizophrenia. However, clozapine can induce arrhythmias in patients. Currently, there is a lack of systematic research on the types and incidence of clozapine-induced arrhythmias.Objective To explore the types and incidence of arrhythmias in patients with schizophrenia induced by clozapine through Meta-analysis, so as to provide references for clinical treatment.Methods On October 31, 2022, a search was conducted through PubMed, Embase, Cochrane Library and China National Knowledge Infrastructure (CNKI) to collect relevant literature on clozapine-induced arrhythmia in patients with schizophrenia. Joanna Briggs Institute (JBI) was used to evaluate the quality of the included literature. Meta-analysis was conducted using Review Manager 5.4.Results A total of 12 studies were included, involving 42 490 schizophrenia patients taking clozapine. The incidence of arrhythmias caused by clozapine was 23% (95% CI: 0.16~0.29). Among them, the incidence of tachycardia was 25% (95% CI: 0.15~0.35), atrial arrhythmia was 6% (95% CI: -0.02~0.14), ventricular arrhythmia was 7% (95% CI: -0.02~0.16), conduction block was 2% (95% CI: 0~0.04), QTc prolongation was 4% (95% CI: -0.04~0.12) and T-wave changes was 23% (95% CI: 0.16~0.30).Conclusion Schizophrenia patients taking clozapine may increase their risk of developing arrhythmia, with tachycardia being the most prevalent. [Funded by Graduate Innovation Fund of Kunming Medical University (number, 2023S302)]
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