| Chen Yadi,Ding Yu,Li Qianqian,Liu Xiaolei,Wang Weiwei,Arrhythmia induced by clozapine in patients with schizophrenia： a Meta-analysis[J].SICHUAN MENTAL HEALTH,2024,37(5):475-481 |
| Arrhythmia induced by clozapine in patients with schizophrenia： a Meta-analysis |
DOI：10.11886/scjsws20231211002 |
| English keywords:Clozapine Schizophrenia Arrhythmias Meta-analysis |
| Fund projects:国家自然科学基金（项目名称：基于树鼩TRS模型研究乳酸代谢异常在CIM过程中的机制，项目编号：NO.82360275）；云南省科技厅科技计划项目（项目名称：miRNAs交叉串话介导JAK2/STAT3通路参与SCU对抗I/R心肌细胞调亡机制研究，项目编号：202301AY070001-020）；云南省教育厅科学研究基金项目（项目名称：NLRP3在灯盏花素抑制I/R所致心肌细胞焦亡过程中的机制研究，项目编号：2023Y0640）；昆明医科大学研究生创新基金（项目名称：氯氮平对TRS患者心脏损伤研究，项目编号：2023S302） |
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| Background Clozapine belongs to atypical antipsychotic drugs that has shown significant efficacy in treating schizophrenia. However， clozapine can induce arrhythmias in patients. Currently， there is a lack of systematic research on the types and incidence of clozapine-induced arrhythmias.Objective To explore the types and incidence of arrhythmias in patients with schizophrenia induced by clozapine through Meta-analysis， so as to provide references for clinical treatment.Methods On October 31， 2022， a search was conducted through PubMed， Embase， Cochrane Library and China National Knowledge Infrastructure （CNKI） to collect relevant literature on clozapine-induced arrhythmia in patients with schizophrenia. Joanna Briggs Institute （JBI） was used to evaluate the quality of the included literature. Meta-analysis was conducted using Review Manager 5.4.Results A total of 12 studies were included， involving 42 490 schizophrenia patients taking clozapine. The incidence of arrhythmias caused by clozapine was 23% （95% CI： 0.16~0.29）. Among them， the incidence of tachycardia was 25% （95% CI： 0.15~0.35）， atrial arrhythmia was 6% （95% CI： -0.02~0.14）， ventricular arrhythmia was 7% （95% CI： -0.02~0.16）， conduction block was 2% （95% CI： 0~0.04）， QTc prolongation was 4% （95% CI： -0.04~0.12） and T-wave changes was 23% （95% CI： 0.16~0.30）.Conclusion Schizophrenia patients taking clozapine may increase their risk of developing arrhythmia， with tachycardia being the most prevalent. ［Funded by Graduate Innovation Fund of Kunming Medical University （number， 2023S302）］ |
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