Wang Yuxiang,Zhang Luoya,Zhang Maomao,Deng Juan,Peng Yanjie,Cheng Xiaotong,Liu Kezhi,Lei Wei,Chen Jing,Decision-making behavior in patients with depressive disorder and its relationship with depressive and anxiety symptoms[J].SICHUAN MENTAL HEALTH,2025,38(1):22-27

Decision-making behavior in patients with depressive disorder and its relationship with depressive and anxiety symptoms

DOI：10.11886/scjsws20240614001

English keywords:Depressive disorder Decision-making behavior Probability reversal learning Depressive and anxiety symptoms

Fund projects:2019年度泸州科技局-西南医科大学联合项目（项目名称：抑郁症目标导向-习惯学习系统异常及其神经机制，项目编号：2019LZXNYDJ39）

Author Name	Affiliation	Postcode
Wang Yuxiang	Affiliated Hospital of Southwest Medical University， Luzhou 646000， China Southwest Medical University， Luzhou 646000， China	646000
Zhang Luoya	Affiliated Hospital of Southwest Medical University， Luzhou 646000， China	646000
Zhang Maomao	Affiliated Hospital of Southwest Medical University， Luzhou 646000， China	646000
Deng Juan	Southwest Medical University， Luzhou 646000， China	646000
Peng Yanjie	Southwest Medical University， Luzhou 646000， China	646000
Cheng Xiaotong	Sichuan Mental Health Center·The Third Hospital of Mianyang， Mianyang 621000， China	621000
Liu Kezhi	Affiliated Hospital of Southwest Medical University， Luzhou 646000， China Zigong Mental Health Center， Zigong 643000， China	643000
Lei Wei	Affiliated Hospital of Southwest Medical University， Luzhou 646000， China	646000
Chen Jing^*	Affiliated Hospital of Southwest Medical University， Luzhou 646000， China	646000

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English abstract:

Background Patients with depressive disorder often exhibit impaired decision-making functions. However， the relationship between decision-making abilities and depressive and anxiety symptoms in these patients remains unclear.Objective To explore the characteristics of decision-making behavior in patients with depressive disorder， and to analyze its relationship with clinical symptoms.Methods A total of 48 patients diagnosed with depressive disorder according to the Diagnostic and Statistical Manual of Mental Disorders， fourth edition （DSM-IV） were recruited from the Department of Psychosomatic Medicine of the Affiliated Hospital of Southwest Medical University from October 2020 to May 2023. Concurrently， 52 healthy individuals matched for age and gender were recruited from Luzhou as the control group. Beck Depression Inventory （BDI） and Beck Anxiety Inventory （BAI） were used for assessment， and decision-making behavior was evaluated using Probabilistic Reversal Learning （PRL） task. Indicators assessed included the number of trials to criterion， perseverative errors， win-stay rate and lose-shift rate. Spearman correlation analysis was used to assess the correlation between BDI and BAI scores and PRL task indicators.Results The depression group showed a significantly higher lose-shift rate compared with the control group （t=3.684， P<0.01）. There were no statistically significant differences between two groups in trials to criterion， perseverative errors and win-stay rate （t=0.329， 0.132， 0.609， P>0.05）. In depression group， BDI and BAI scores were positively correlated with the win-stay rate（r=0.450， 0.398， P<0.01）.Conclusion Patients with depressive disorder are more likely to change their decision-making strategies following negative outcomes. Furthermore， the severity of depressive and anxiety symptoms is associated with a greater propensity to maintain existing decisions after receiving positive feedback. ［Funded by 2019 Joint Project of Luzhou Science and Technology Bureau-Southwest Medical University （number， 2019LZXNYDJ39］

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